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Host and environmental factors for gastric cancer in Babol, the Caspian Sea Coast, Iran
- Source :
- European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP). 16(3)
- Publication Year :
- 2007
-
Abstract
- To clarify host and environmental factors for gastric carcinogenesis, we obtained information about gastric cancer mortality in Babol, in the North of Iran, and recruited 130 participants aged 30-80 years from the general population of Babol in 2004. A urea breath test, assessment of IgG antibodies to Helicobacter pylori, a pepsinogen test, a marker of chronic atrophic gastritis, and determination of urinary excretions of sodium and potassium were performed. Diet and lifestyle information was also obtained using a questionnaire. The stomach cancer mortality rate for men in Babol (38.2/10 5 ) was found to be somewhat lower than that for Japanese men (45.1 /10 5 ), while the mortality for women (26.9/10 5 ) was higher than for Japanese women (20.9/10 5 ). Positive rates for the urea breath test were 77.5 and 81.8% for Iranian men and women, respectively. Helicobacter pylori IgG antibodies were present in 68.7 and 73.7% of Iranian men and women, respectively, both values being marginally higher than for Japanese. We also found 51.0 and 52.8% to be positive for a pepsinogen test, significantly higher than the Japanese values. Urinary excretions of salt and potassium in this population appeared approximately the same as the consumption in Japanese. The elevated gastric cancer mortality in both men and women in Babol seems, by and large, to be related to higher H. pylori infection rates and prevalence of chronic atrophic gastritis. Certain factors, including H. pylori DNA diversity, host factors and their interactions, together with the level of medical practice, prevalence of and access to secondary prevention of stomach cancer, may also be associated with the relatively high mortality.
- Subjects :
- Adult
Male
Cancer Research
medicine.medical_specialty
Alcohol Drinking
Epidemiology
Atrophic gastritis
Urea breath test
Population
Iran
Gastroenterology
White People
Helicobacter Infections
Pepsin
Asian People
Japan
Risk Factors
Stomach Neoplasms
Internal medicine
Medicine
Humans
education
Stomach cancer
Aged
Aged, 80 and over
education.field_of_study
biology
medicine.diagnostic_test
Helicobacter pylori
business.industry
Mortality rate
Smoking
Sodium
Public Health, Environmental and Occupational Health
Cancer
Middle Aged
biology.organism_classification
medicine.disease
Antibodies, Bacterial
Diet
Oncology
Breath Tests
biology.protein
Potassium
Female
business
Subjects
Details
- ISSN :
- 09598278
- Volume :
- 16
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)
- Accession number :
- edsair.doi.dedup.....ed818e0c4683db5876523c477740e7c3