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Neural Hyporesponsiveness and Hyperresponsiveness During Immediate and Delayed Reward Processing in Adult Attention-Deficit/Hyperactivity Disorder
- Source :
- Biological Psychiatry. 65:7-14
- Publication Year :
- 2009
- Publisher :
- Elsevier BV, 2009.
-
Abstract
- Background Dysfunctional reward processing, accompanied by a limited ability to tolerate reward delays, has been proposed as an important feature in attention-deficit/hyperactivity disorder (ADHD). Methods Using functional magnetic resonance imaging (fMRI), brain activation in adult patients with ADHD ( n = 14) and healthy control subjects ( n = 12) was examined during a series of choices between two monetary reward options that varied by delay to delivery. Results Compared with healthy control subjects, hyporesponsiveness of the ventral-striatal reward system was replicated in patients with ADHD and was evident for both immediate and delayed rewards. In contrast, delayed rewards evoked hyperactivation in dorsal caudate nucleus and amygdala of ADHD patients. In both structures, neural activity toward delayed rewards was significantly correlated with self-rated ADHD symptom severity. Conclusions The finding of ventral-striatal hyporesponsiveness during immediate and delayed reward processing in patients with ADHD further strengthens the concept of a diminished neural processing of rewards in ADHD. Hyperactivation during delayed reward processing, gradually increasing along the ventral-to-dorsal extension of the caudate nucleus, and especially the concomitant hyperactivation of the amygdala are in accordance with predictions of the delay aversion hypothesis.
- Subjects :
- Adult
Male
Caudate nucleus
Dysfunctional family
Striatum
Choice Behavior
Amygdala
Basal Ganglia
Developmental psychology
Reward system
Reward
mental disorders
Image Processing, Computer-Assisted
medicine
Humans
Attention deficit hyperactivity disorder
Biological Psychiatry
Brain Mapping
medicine.diagnostic_test
Hyperactivation
Brain
medicine.disease
Magnetic Resonance Imaging
medicine.anatomical_structure
Attention Deficit Disorder with Hyperactivity
Caudate Nucleus
Functional magnetic resonance imaging
Psychology
Neuroscience
psychological phenomena and processes
Subjects
Details
- ISSN :
- 00063223
- Volume :
- 65
- Database :
- OpenAIRE
- Journal :
- Biological Psychiatry
- Accession number :
- edsair.doi.dedup.....ed866d95faf4a2cf9cde48f24521d179