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Subjective Cognitive Decline Is Associated With Altered Default Mode Network Connectivity in Individuals With a Family History of Alzheimer's Disease

Authors :
Sander C.J. Verfaillie
Alexa Pichet Binette
Etienne Vachon-Presseau
Shirin Tabrizi
Mélissa Savard
Pierre Bellec
Rik Ossenkoppele
Philip Scheltens
Wiesje M. van der Flier
John C.S. Breitner
Sylvia Villeneuve
Paul Aisen
Elena Anthal
Melissa Appleby
Gülebru Ayranci
Alan Barkun
Thomas Beaudry
Fatiha Benbouhoud
Veronique Bohbot
Jason Brandt
John Breitner
Leopoldina Carmo
Edouard Carrier Charles
Mallar Chakravarty
Laksanun Cheewakriengkrai
Louis Collins
Blandine Courcot
Doris Couture
Suzanne Craft
Claudio Cuello
Mahsa Dadar
Christian Dansereau
null DasSamir
Dauar-Tedeschi Marina
Doris Dea
Clement Debacker
Rene Desautels
Sylvie Dubuc
Guerda Duclair
Marianne Dufour
Mark Eisenberg
Rana El-Khoury
Pierre Etienne
Alan Evans
Anne-Marie Faubert
Fabiola Ferdinand
Vladimir Fonov
David Fontaine
Josée Frappier
Frenette Joanne
Guylaine Gagne
Serge Gauthier
Valérie Gervais
Renuka Giles
Julie Gonneaud
Renee Gordon
Rick Hoge
Bradley Hyman
Yasser Ituria-Medina
Clifford Jack
Justin Kat
Christina Kazazian
Zaven Khachaturian
David Knopman
Penelope Kostopoulos
Anne Labonte
Marie-Elyse Lafaille-Magnan
Tanya Lee
Jeannie-Marie Leoutsakos
Claude Lepage
Illana Leppert
Cécile Madjar
Laura Mahar
David Maillet
Jean-Robert Maltais
Axel Mathieu
Sulantha Mathotaarachchi
Gerhard Maultaup
Ginette Mayrand
Pierre-François Meyer
Diane Michaud
Justin Miron
Thomas Montine
John Morris
Lisa-Marie Münter
Vasavan Nair
Jamie Near
Holly Newbold-Fox
Pierre Orban
Véronique Page
Tharick Pascoal
Mirela Petkova
Cynthia Picard
Galina Pogossova
Judes Poirier
Jens Pruessner
Natasha Rajah
Pierre Rioux
Pedro Rosa-Neto
Mark Sager
Eunice Farah Saint-Fort
Reisa Sperling
Angela Tam
Christine Tardif
Pierre Tariot
Eduard Teigner
Louise Theroux
Ronald Thomas
Paule-Joanne Toussaint
Jennifer Tremblay-Mercier
Miranda Tuwaig
Isabelle Vallee
Vinod Venugopalan
Sander Verfaillie
Jacob Vogel
Karen Wan
Seqian Wang
Elsa Yu
Radiology and nuclear medicine
Amsterdam Neuroscience - Neurodegeneration
Neurology
APH - Personalized Medicine
APH - Methodology
Source :
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 3(5), 463-472. Elsevier Inc., Verfaillie, S, Pichet Binette, A, Vachon-Presseau, E, Tabrizi, S, Savard, M, Bellec, P, Ossenkoppele, R, Scheltens, P, van der Flier, W M, Breitner, J C S, Villeneuve, S, Aisen, P, Anthal, E, Appleby, M, Ayranci, G, Barkun, A, Beaudry, T, Bellec, P, Benbouhoud, F, Bohbot, V, Brandt, J, Breitner, J, Carmo, L, Carrier Charles, E, Chakravarty, M, Cheewakriengkrai, L, Collins, L, Courcot, B, Couture, D, Craft, S, Cuello, C, Dadar, M, Dansereau, C, DasSamir, Marina, D T, Dea, D, Debacker, C, Desautels, R, Dubuc, S, Duclair, G, Dufour, M, Eisenberg, M, El-Khoury, R, Etienne, P, Evans, A, Faubert, A M, Ferdinand, F, Fonov, V, Vogel, J & PREVENT-AD Research Group 2018, ' Subjective Cognitive Decline Is Associated With Altered Default Mode Network Connectivity in Individuals With a Family History of Alzheimer's Disease ', Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, vol. 3, no. 5, pp. 463-472 . https://doi.org/10.1016/j.bpsc.2017.11.012
Publication Year :
2018

Abstract

Background: Both subjective cognitive decline (SCD) and a family history of Alzheimer's disease (AD) portend risk of brain abnormalities and progression to dementia. Posterior default mode network (pDMN) connectivity is altered early in the course of AD. It is unclear whether SCD predicts similar outcomes in cognitively normal individuals with a family history of AD. Methods: We studied 124 asymptomatic individuals with a family history of AD (age 64 ± 5 years). Participants were categorized as having SCD if they reported that their memory was becoming worse (SCD+). We used extensive neuropsychological assessment to investigate five different cognitive domain performances at baseline (n = 124) and 1 year later (n = 59). We assessed interconnectivity among three a priori defined ROIs: pDMN, anterior ventral DMN, medial temporal memory system (MTMS), and the connectivity of each with the rest of brain. Results: Sixty-eight (55%) participants reported SCD. Baseline cognitive performance was comparable between groups (all false discovery rate-adjusted p values >.05). At follow-up, immediate and delayed memory improved across groups, but the improvement in immediate memory was reduced in SCD+ compared with SCD− (all false discovery rate–adjusted p values −, SCD+ subjects showed increased pDMN–MTMS connectivity (false discovery rate–adjusted p

Details

Language :
English
ISSN :
24519022
Database :
OpenAIRE
Journal :
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 3(5), 463-472. Elsevier Inc., Verfaillie, S, Pichet Binette, A, Vachon-Presseau, E, Tabrizi, S, Savard, M, Bellec, P, Ossenkoppele, R, Scheltens, P, van der Flier, W M, Breitner, J C S, Villeneuve, S, Aisen, P, Anthal, E, Appleby, M, Ayranci, G, Barkun, A, Beaudry, T, Bellec, P, Benbouhoud, F, Bohbot, V, Brandt, J, Breitner, J, Carmo, L, Carrier Charles, E, Chakravarty, M, Cheewakriengkrai, L, Collins, L, Courcot, B, Couture, D, Craft, S, Cuello, C, Dadar, M, Dansereau, C, DasSamir, Marina, D T, Dea, D, Debacker, C, Desautels, R, Dubuc, S, Duclair, G, Dufour, M, Eisenberg, M, El-Khoury, R, Etienne, P, Evans, A, Faubert, A M, Ferdinand, F, Fonov, V, Vogel, J & PREVENT-AD Research Group 2018, ' Subjective Cognitive Decline Is Associated With Altered Default Mode Network Connectivity in Individuals With a Family History of Alzheimer's Disease ', Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, vol. 3, no. 5, pp. 463-472 . https://doi.org/10.1016/j.bpsc.2017.11.012
Accession number :
edsair.doi.dedup.....ed8cda6d05a5aa4e5888d45b2dcc13a2
Full Text :
https://doi.org/10.1016/j.bpsc.2017.11.012