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Lycopene inhibits the cell proliferation and invasion of human head and neck squamous cell carcinoma
- Source :
- Molecular Medicine Reports
- Publication Year :
- 2016
- Publisher :
- Spandidos Publications, 2016.
-
Abstract
- Lycopene has been shown to be associated with anticancer effects in numerous tumor types. However, the underlying mechanisms of lycopene in human head and neck squamous cell carcinoma (HNSCC) remain to be determined. The present study aimed to investigate the involvement of lycopene overload and the cytotoxic effects of lycopene on HNSCC cells, and to determine the possible mechanisms involved. Treatment with lycopene at a dose of >10 µM for >24 h inhibited the growth of FaDu and Cal27 cells in a time- and dose-dependent manner. The clearest increase in growth inhibition was due to the apoptotic population being significantly increased. The invasion abilities decreased with 25 µM lycopene exerting significant inhibitory effects (P
- Subjects :
- 0301 basic medicine
Oncology
Cancer Research
medicine.medical_specialty
Population
Apoptosis
HNSCC
Biochemistry
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Cell Line, Tumor
Internal medicine
Genetics
medicine
Anticarcinogenic Agents
Humans
Neoplasm Invasiveness
Protein kinase A
education
Molecular Biology
Protein kinase B
education.field_of_study
Cell growth
Articles
Cell cycle
lycopene
cell invasion
Carotenoids
Lycopene
cell proliferation
030104 developmental biology
chemistry
Head and Neck Neoplasms
030220 oncology & carcinogenesis
Carcinoma, Squamous Cell
Cancer research
Molecular Medicine
Growth inhibition
A431 cells
Subjects
Details
- ISSN :
- 17913004 and 17912997
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Molecular Medicine Reports
- Accession number :
- edsair.doi.dedup.....ed9a3d1b9767961a703e05666e6577d7