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Antiangiogenic Effect of Capecitabine Combined with Ginsenoside Rg3 on Breast Cancer in Mice
- Source :
- Cancer Biotherapy and Radiopharmaceuticals. 23:647-654
- Publication Year :
- 2008
- Publisher :
- Mary Ann Liebert Inc, 2008.
-
Abstract
- Capecitabine is a novel fluoropyrimidine carbamate, which has a broader spectrum of antitumor activity than other fluoropyrimidines, such as 5-FU, DFUR, or UFT; it has proved effective over a wide dose range. Recent research has suggested that frequent administration of lower doses of certain chemotherapeutic drugs might enhance their antiangiogenic effect. The present study investigated the antiangiogenic effect of capecitabine on breast cancer. In order to augment its efficacy, we combined capecitabine chemotherapy with ginsenoside Rg3. Our results indicate that a metronomic regimen of capecitabine inhibited angiogenesis in breast cancer, and its antiangiogenic effects may be further enhanced by the concurrent administration of ginsenoside Rg3. As an antiangiogenic method, this regimen presented better antitumor effects, less toxicity, and reduced susceptibility to drug resistance.
- Subjects :
- Vascular Endothelial Growth Factor A
Antimetabolites, Antineoplastic
Cancer Research
Time Factors
Ginsenosides
Angiogenesis
medicine.medical_treatment
Angiogenesis Inhibitors
Mammary Neoplasms, Animal
Drug resistance
Pharmacology
Deoxycytidine
Capecitabine
Mice
chemistry.chemical_compound
Breast cancer
Cell Line, Tumor
medicine
Animals
Humans
Radiology, Nuclear Medicine and imaging
Mice, Inbred BALB C
Chemotherapy
Neovascularization, Pathologic
business.industry
General Medicine
medicine.disease
Immunohistochemistry
Regimen
Oncology
chemistry
Ginsenoside
Toxicity
Female
Fluorouracil
business
medicine.drug
Subjects
Details
- ISSN :
- 15578852 and 10849785
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- Cancer Biotherapy and Radiopharmaceuticals
- Accession number :
- edsair.doi.dedup.....edaa5ce10f563987bdbf9df7744782c9