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Advances in novel antibiotics to treat multidrug-resistant gram-negative bacterial infections
- Source :
- Internal and Emergency Medicine
- Publication Year :
- 2020
-
Abstract
- Antimicrobial resistance is a growing threat to public health and an increasingly common problem for acute care physicians to confront. Several novel antibiotics have been approved in the past decade to combat these infections; however, physicians may be unfamiliar with how to appropriately utilize them. The purpose of this review is to evaluate novel antibiotics active against resistant gram-negative bacteria and highlight clinical information regarding their use in the acute care setting. This review focuses on novel antibiotics useful in the treatment of infections caused by resistant gram-negative organisms that may be seen in the acute care setting. These novel antibiotics include ceftolozane/tazobactam, ceftazidime/avibactam, meropenem/vaborbactam, imipenem/cilistatin/relebactam, cefiderocol, plazomicin, eravacycline, and omadacycline. Acute care physicians should be familiar with these novel antibiotics so they can utilize them appropriately.
- Subjects :
- medicine.medical_specialty
Tazobactam
medicine.drug_class
Avibactam
Antibiotics
Resistance
Cilastatin, Imipenem Drug Combination
030204 cardiovascular system & hematology
Plazomicin
Ceftazidime
03 medical and health sciences
chemistry.chemical_compound
Heterocyclic Compounds, 1-Ring
0302 clinical medicine
Antibiotic resistance
Acute care
EM - Review
Omadacycline
Gram-Negative Bacteria
Internal Medicine
Medicine
Humans
Multidrug-resistant
030212 general & internal medicine
Intensive care medicine
Novel
business.industry
Meropenem
Eravacycline
Boronic Acids
Drug Resistance, Multiple
Anti-Bacterial Agents
Cephalosporins
Drug Combinations
chemistry
Tetracyclines
Drug Design
Emergency Medicine
Sisomicin
Ceftolozane
business
Gram-Negative Bacterial Infections
Azabicyclo Compounds
Subjects
Details
- ISSN :
- 19709366
- Volume :
- 16
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Internal and emergency medicine
- Accession number :
- edsair.doi.dedup.....edaab4860b35e81d827dbcb28476df66