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Selected Natural Products in Neuroprotective Strategies for Alzheimer’s Disease—A Non-Systematic Review

Authors :
Karolina Wojtunik-Kulesza
Tomasz Oniszczuk
Jarosław Mołdoch
Iwona Kowalska
Jarosław Szponar
Anna Oniszczuk
Source :
International Journal of Molecular Sciences, Vol 23, Iss 1212, p 1212 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

Neurodegenerative disorders such as Alzheimer’s disease (AD) are distinguished by the irreversible degeneration of central nervous system function and structure. AD is characterized by several different neuropathologies—among others, it interferes with neuropsychiatrical controls and cognitive functions. This disease is the number one neurodegenerative disorder; however, its treatment options are few and, unfortunately, ineffective. In the new strategies devised for AD prevention and treatment, the application of plant-based natural products is especially popular due to lesser side effects associated with their taking. Moreover, their neuroprotective activities target different pathological mechanisms. The current review presents the anti-AD properties of several natural plant substances. The paper throws light on products under in vitro and in vivo trials and compiles information on their mechanism of actions. Knowledge of the properties of such plant compounds and their combinations will surely lead to discovering new potent medicines for the treatment of AD with lesser side effects than the currently available pharmacological proceedings.

Details

Language :
English
ISSN :
16616596 and 14220067
Volume :
23
Issue :
1212
Database :
OpenAIRE
Journal :
International Journal of Molecular Sciences
Accession number :
edsair.doi.dedup.....edb1bd222ffa79ad7acf232c4291826a