Back to Search
Start Over
Primary tumour PSMA intensity is an independent prognostic biomarker for biochemical recurrence-free survival following radical prostatectomy
- Source :
- European journal of nuclear medicine and molecular imaging. 49(9)
- Publication Year :
- 2021
-
Abstract
- Purpose The prognostic value of PSMA intensity on PSMA PET/CT due to underlying biology and subsequent clinical implications is an emerging topic of interest. We sought to investigate whether primary tumour PSMA PET intensity contributes to pre- and post-operative prediction of oncological outcomes following radical prostatectomy. Methods We performed a retrospective cohort study of 848 men who underwent all of multiparametric MRI (mpMRI), transperineal prostate biopsy, and 68 Ga-PSMA PET/CT prior to radical prostatectomy. PSMA intensity, quantified as maximum standard uptake value (SUVmax), and other clinical variables were considered relative to post-operative biochemical recurrence-free survival (BRFS) using Cox regression and Kaplan–Meier analysis. Results After a median follow-up of 41 months, 219 events occurred; the estimated 3-year BRFS was 79% and the 5-year BRFS was 70%. Increasing PSMA intensity was associated with less favourable BRFS overall (Log rank p p Conclusion These results in a large series of patients confirm PSMA intensity to be a novel, independent prognostic factor for BRFS.
Details
- ISSN :
- 16197089
- Volume :
- 49
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- European journal of nuclear medicine and molecular imaging
- Accession number :
- edsair.doi.dedup.....edb7e3f8579876af4e702287e3262e5d