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Ketogenic diet reduces alcohol withdrawal symptoms in humans and alcohol intake in rodents
- Source :
- Science Advances, Wiers, C E, Vendruscolo, L F, van der Veen, J W, Manza, P, Shokri-Kojori, E, Kroll, D S, Feldman, D E, McPherson, K L, Biesecker, C L, Zhang, R, Herman, K, Elvig, S K, Vendruscolo, J C M, Turner, S A, Yang, S, Schwandt, M, Tomasi, D, Cervenka, M C, Fink-Jensen, A, Benveniste, H, Diazgranados, N, Wang, G J, Koob, G F & Volkow, N D 2021, ' Ketogenic diet reduces alcohol withdrawal symptoms in humans and alcohol intake in rodents ', Science Advances, vol. 7, no. 15, eabf6780 . https://doi.org/10.1126/SCIADV.ABF6780
- Publication Year :
- 2021
- Publisher :
- American Association for the Advancement of Science, 2021.
-
Abstract
- A ketogenic diet lowered benzodiazepine use during withdrawal in patients with AUD and blunted alcohol administration in rats.<br />Individuals with alcohol use disorder (AUD) show elevated brain metabolism of acetate at the expense of glucose. We hypothesized that a shift in energy substrates during withdrawal may contribute to withdrawal severity and neurotoxicity in AUD and that a ketogenic diet (KD) may mitigate these effects. We found that inpatients with AUD randomized to receive KD (n = 19) required fewer benzodiazepines during the first week of detoxification, in comparison to those receiving a standard American (SA) diet (n = 14). Over a 3-week treatment, KD compared to SA showed lower “wanting” and increased dorsal anterior cingulate cortex (dACC) reactivity to alcohol cues and altered dACC bioenergetics (i.e., elevated ketones and glutamate and lower neuroinflammatory markers). In a rat model of alcohol dependence, a history of KD reduced alcohol consumption. We provide clinical and preclinical evidence for beneficial effects of KD on managing alcohol withdrawal and on reducing alcohol drinking.
- Subjects :
- medicine.medical_specialty
medicine.medical_treatment
Alcohol
Alcohol use disorder
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
Detoxification
mental disorders
medicine
Anterior cingulate cortex
Research Articles
030304 developmental biology
0303 health sciences
Multidisciplinary
business.industry
Alcohol dependence
Glutamate receptor
Neurotoxicity
SciAdv r-articles
medicine.disease
medicine.anatomical_structure
Endocrinology
chemistry
business
030217 neurology & neurosurgery
Ketogenic diet
Research Article
Neuroscience
Subjects
Details
- Language :
- English
- ISSN :
- 23752548
- Volume :
- 7
- Issue :
- 15
- Database :
- OpenAIRE
- Journal :
- Science Advances
- Accession number :
- edsair.doi.dedup.....edddaedd6743d3e3d2348d2e67fe0cf6