Surgically-induced knee osteoarthritis in mice is attenuated by pharmacological liver X receptor activation

Authors :: Schmidt, Tobias
Behler-Janbeck, Friederike
Rüther, Wolfgang
Dell'Accio, Francesco
Niemeier, Andreas
Source :: Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2018); 20181023-20181026; Berlin; DOCPT12-968 /20181106/
Publication Year :: 2018
Publisher :: German Medical Science GMS Publishing House; Düsseldorf, 2018.
Abstract: Objectives: The Liver X Receptors (LXRalpha and LXRbeta)are nuclear receptors with established roles in lipid metabolism and inflammatory signaling. Recent in vitro studies have suggested that LXRs are expressed in articular cartilage tissue and that LXR activation may offer protection against osteoarthritis[for full text, please go to the a.m. URL]<br />Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2018)

Subjects :: ddc: 610
Osteoarthritis
nuclear receptors
lipids (amino acids, peptides, and proteins)
610 Medical sciences
Medicine
cartilage

Language :: English
Database :: OpenAIRE
Journal :: Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2018); 20181023-20181026; Berlin; DOCPT12-968 /20181106/
Accession number :: edsair.doi.dedup.....edf63868507fcbcaa54e628951d99a94

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