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Elevated mean corpuscular volume as a predictor of hematologic toxicity due to methotrexate therapy
- Source :
- Arthritis & Rheumatism. 32:1592-1596
- Publication Year :
- 1989
- Publisher :
- Wiley, 1989.
-
Abstract
- Retrospective analysis of 23 rheumatoid arthritis patients receiving low-dose methotrexate (MTX) demonstrated an association between the mean corpuscular volume (MCV) and hematologic toxicity. All 6 patients who developed hematologic toxicity were folate deficient, and 4 of 6 had marked macrocytosis. Furthermore, the mean MCV of the patients who developed toxicity was significantly higher than that of the controls without toxicity (P less than 0.02). This difference in MCV was associated with an increased probability of developing toxicity with time (P less than 0.005). These results suggest that sustained elevation in the MCV may be a predictor of impending hematologic toxicity due to folate depletion.
- Subjects :
- Male
medicine.medical_specialty
Immunology
Arthritis
Macrocytosis
Gastroenterology
Arthritis, Rheumatoid
chemistry.chemical_compound
Rheumatology
Internal medicine
Humans
Immunology and Allergy
Medicine
Pharmacology (medical)
Mean corpuscular volume
Survival analysis
Aged
Retrospective Studies
medicine.diagnostic_test
business.industry
Middle Aged
medicine.disease
Hematologic Diseases
Survival Analysis
Blood Cell Count
Blood
Methotrexate
Endocrinology
chemistry
Rheumatoid arthritis
Toxicity
Antifolate
Female
business
Forecasting
circulatory and respiratory physiology
medicine.drug
Subjects
Details
- ISSN :
- 15290131 and 00043591
- Volume :
- 32
- Database :
- OpenAIRE
- Journal :
- Arthritis & Rheumatism
- Accession number :
- edsair.doi.dedup.....ee04529edb349e7f634083abe85dd8ee
- Full Text :
- https://doi.org/10.1002/anr.1780321214