The Clinical Characteristics of Fever-Ward Pediatric Patients with a Definite Epidemiological History During the Early COVID-19 Epidemic Period

Wenliang Song,1,&ast; Junhua Li,2,&ast; Ning Zou,1 Wenhe Guan,1 Jiali Pan,1 Wei Xu1 1Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang City, Liaoning Province, People’s Republic of China; 2Department of Pediatrics, Central Hospital of XiangYang City, Xiangyang City, Hubei Province, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Wei XuDepartment of Pediatrics, Shengjing Hospital of China Medical University, Shenyang City, Liaoning Province, People’s Republic of ChinaEmail tomxu.123@163.comObjective: The number of children presenting with coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection is increasing, and we aimed to assess the clinical characteristics of pediatric patients with a definite epidemiological history during the early COVID-19 epidemic.Methods: Retrospective analysis was performed on the clinical data of children admitted to the fever ward of Xiangyang Central Hospital in Hubei province between January 1, 2020 and March 17, 2020. According to definite epidemiological history, patients with SARS-CoV-2 nucleic acid test (NAT) positive detection were grouped as confirmed cases, and patients with two consecutive negative NATs were grouped as suspected cases. We compared the clinical characteristics of the two groups.Results: A total of 47 (47/127, 37%) cases had a definite epidemiological history, of which 32 (68.1%) were suspected, with a median age of 5.5 years (interquartile range [IQR]: 0.7– 10.3), and 15 (31.9%) were confirmed, with a median age of 9 years (IQR: 4– 14). Statistically significant differences in age, family cluster of infection, and numbers of patients with clinical symptoms and fever (P< 0.05) were found between the two groups, but no statistically significant differences in leucocyte and lymphocyte counts were observed (P> 0.05). Significant differences were found in the computed tomography (CT) manifestation of ground glass opacity (GGO) between the two groups (P< 0.05).Conclusion: Children of older age and from family clusters of infection were more easily diagnosed as having COVID-19. GGO changes on chest CT was more likely in confirmed cases. Although obvious clinical manifestations increase our awareness of COVID-19, children without manifestations of fever or cough should not be ignored as they may be asymptomatic carriers.Keywords: novel coronavirus disease, COVID-19, SARS-CoV-2, children, clinical manifestation