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Nanoparticles-stacked superhydrophilic coating supported synergistic antimicrobial ability for enhanced wound healing
- Source :
- Materials Science and Engineering: C. 132:112535
- Publication Year :
- 2022
- Publisher :
- Elsevier BV, 2022.
-
Abstract
- Medical device infections have now become the major burden of healthcare, and particular administration of combating bacterial infections is of significance. In this work, robust nanoparticles-stacked superhydrophilic coatings were established through the rapid oxidation, cross-linking and aggregation of dopamine in the presence of sodium periodate. The robust superhydrophilicity was achieved and maintained due to the hydrophilic chemical components together with the micro/nano topological structure stacked by nanoparticles, resulting in an impressive nonfouling performance for proteins adsorption. Moreover, due to the presence of aromatic catechol moieties, antibiotics (e.g. norfloxacin and cephalexin) were deposited into the superhydrophilic coating in situ, by π-π stacking/hydrophobic interactions, endowing the surface with antibacterial ability. Interestingly, the superhydrophilic coatings showed a safe and effective antibacterial ability in a low dose-dependent manner because of the nonfouling platform supported killing and releasing of bacteria. The in vivo cutaneous wound healing evaluation in rats further demonstrated the synchronous effect of anti-infection and promoting wound healing. Such superhydrophilicity supported nonfouling platform was believed to open a new window to modify biomedical devices combined with wound healing and antibacterial properties.
- Subjects :
- Materials science
Nanoparticle
Bioengineering
Nanotechnology
engineering.material
Biomaterials
Hydrophobic effect
chemistry.chemical_compound
Coating
Superhydrophilicity
medicine
Animals
Norfloxacin
Wound Healing
Sodium periodate
Antimicrobial
Anti-Bacterial Agents
Rats
chemistry
Mechanics of Materials
engineering
Nanoparticles
Adsorption
Wound healing
Hydrophobic and Hydrophilic Interactions
medicine.drug
Subjects
Details
- ISSN :
- 09284931
- Volume :
- 132
- Database :
- OpenAIRE
- Journal :
- Materials Science and Engineering: C
- Accession number :
- edsair.doi.dedup.....ee0f8aa12cb91cb68d630b466a063b51