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Carbon nanotubes buckypapers for potential transdermal drug delivery
- Publication Year :
- 2015
- Publisher :
- Elsevier Science, 2015.
-
Abstract
- Drug loaded buckypapers based on different types of carbon nanotubes (CNTs) were prepared and characterized in order to evaluate their potentialities for the design of novel transdermal drug delivery systems. Lab-synthesized CNTs as well as commercial samples were employed. Clonidine hydrochloride was used as model drug, and the influence of composition of the drug loaded buckypapers and processing variables on in vitro release profiles was investigated. To examine the influence of the drug nature the evaluation was further extended to buckypapers prepared with flurbiprofen and one type of CNTs, their selection being based on the results obtained with the former drug. Scanning electronic microscopy images indicated that the model drugs were finely dispersed on the CNTs. Differential scanning calorimetry, and X-ray diffraction pointed to an amorphous state of both drugs in the buckypapers. A higher degree of CNT-drug superficial interactions resulted in a slower release of the drug. These interactions were in turn affected by the type of CNTs employed (single wall or multiwall CNTs), their functionalization with hydroxyl or carboxyl groups, the chemical structure of the drug, and the CNT:drug mass ratio. Furthermore, the application of a second layer of drug free CNTs on the loaded buckypaper, led to decelerate the drug release and to reduce the burst effect. Fil: Schwengber, Alex. Universidad de Buenos Aires. Programa de Investigación y Desarrollo de Fuentes Alternativas de Materias Primas y Energía; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Prado, Héctor Juan. Universidad de Buenos Aires. Programa de Investigación y Desarrollo de Fuentes Alternativas de Materias Primas y Energía; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Zilli, Dario Adrian. Universidad de Buenos Aires. Programa de Investigación y Desarrollo de Fuentes Alternativas de Materias Primas y Energía; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Bonelli, Pablo Ricardo. Universidad de Buenos Aires. Programa de Investigación y Desarrollo de Fuentes Alternativas de Materias Primas y Energía; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Cukierman, Ana Lea. Universidad de Buenos Aires. Programa de Investigación y Desarrollo de Fuentes Alternativas de Materias Primas y Energía; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
- Subjects :
- Drug
Paper
Materials science
CIENCIAS MÉDICAS Y DE LA SALUD
Chemical structure
media_common.quotation_subject
Ciencias de la Salud
Bioengineering
Nanotechnology
Buckypaper
Carbon nanotube
INGENIERÍAS Y TECNOLOGÍAS
BUCKYPAPERS
Administration, Cutaneous
FLURBIPROFEN
CARBON NANOTUBES
law.invention
Biomaterials
Diffusion
Nanopores
Differential scanning calorimetry
Nanocapsules
law
Materials Testing
Particle Size
media_common
Transdermal
Nanotecnología
Nanotubes, Carbon
Anti-Inflammatory Agents, Non-Steroidal
TRANSDERMAL DRUG DELIVERY
Nano-materiales
Amorphous solid
CLONIDINE HYDROCHLORIDE
Otras Ciencias de la Salud
Absorption, Physicochemical
Flurbiprofen
Mechanics of Materials
Delayed-Action Preparations
Surface modification
Feasibility Studies
Fullerenes
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....ee14f1fb2ea99b19bf2cf88188f60489