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Successful palliative approach with high-intensity focused ultrasound in a patient with metastatic anaplastic pancreatic carcinoma: a case report

Authors :
Francesca Spada
Nicola Fazio
Chiara Casadio
Guido Bonomo
Antonio Ungaro
Anna Maria Frezza
Franco Orsi
Sabina Murgioni
Salvatore Galdy
Paolo Della Vigna
Chiara Alessandra Cella
Clementina Di Tonno
Source :
ecancermedicalscience
Publication Year :
2016

Abstract

We report a case of a 74-year-old man with a metastatic anaplastic pancreatic carcinoma (APC). After an early tumour progression on first-line chemotherapy with cisplatin and gemcitabine, even though it was badly tolerated, he was treated with a combination of systemic modified FOLFIRI and high-intensity focused ultrasound (HIFU) on the pancreatic mass. A tumour showing partial response with a clinical benefit was obtained. HIFU was preferred to radiotherapy because of its shorter course and minimal side effects, in order to improve the patient’s clinical conditions. The patient is currently on chemotherapy, asymptomatic with a good performance status. In referral centres, with specific expertise, HIFU could be safely and successfully combined with systemic chemotherapy for treatment of metastatic pancreatic carcinoma.

Details

Language :
English
Database :
OpenAIRE
Journal :
ecancermedicalscience
Accession number :
edsair.doi.dedup.....ee1dea9ae7aa358ad0225ea61b9164fa