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Association of the TNF-α -308G/A polymorphism with lipid profile changes in response to aerobic training program
- Source :
- Biology of Sport, Vol 36, Iss 3, Pp 291-296 (2019), Biology of Sport
- Publication Year :
- 2019
- Publisher :
- Termedia Publishing House, 2019.
-
Abstract
- Promoter polymorphism of the tumor necrosis factor-α (TNF-α) gene is associated with obesity-related traits, although the role of its potential modifying effect on changes in obesity-related parameters achieved through a training program is still unknown. The aim of the present study was to examine whether the TNF-α-308G/A polymorphism (rs1800629) influences the effects of a training program. Accordingly, we studied the alleles and genotypes distribution in a group of 168 Polish Caucasian women measured for selected body mass and composition, as well as biochemical parameters before and after the realization of a 12-week aerobic training program. Our results showed that TNF-α genotypes can modulate training-induced biochemical parameter changes such as lipid profile. We demonstrated that carriers of the GG genotype are associated with decreases in post-training high-density lipoprotein cholesterol (HDL-C) levels (p
- Subjects :
- medicine.medical_specialty
physical activity
Physical Therapy, Sports Therapy and Rehabilitation
Context (language use)
Biology
sport genetics
tnf-α gene
polymorphism
Polymorphism (computer science)
Physiology (medical)
Internal medicine
Genotype
medicine
Aerobic exercise
Orthopedics and Sports Medicine
Allele
lcsh:Sports medicine
Gene
lcsh:QH301-705.5
Original Paper
medicine.diagnostic_test
TNF-αgene
lipid profile
Endocrinology
lcsh:Biology (General)
Tumor necrosis factor alpha
lipids (amino acids, peptides, and proteins)
Lipid profile
lcsh:RC1200-1245
Subjects
Details
- Language :
- English
- ISSN :
- 20831862
- Volume :
- 36
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Biology of Sport
- Accession number :
- edsair.doi.dedup.....ee2268111aa3978f57cb6f31456a19bd