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Incidence and risk factors of severe non‐proliferative/proliferative diabetic retinopathy: More than a decade follow up in the Tehran Lipids and Glucose Study
- Source :
- Journal of Diabetes Investigation, Vol 13, Iss 2, Pp 317-327 (2022)
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- Aims/Introduction To examine the incidence rate of severe non‐proliferative and proliferative diabetic retinopathy (severe‐NPDR/PDR) and determine its potential risk factors. Materials and Methods The study consisted of 1,169 participants (675 women) with type 2 diabetes mellitus, aged ≥20 years. A trained interviewer collected information about the history of pan‐retinal photocoagulation as a result of diabetic retinopathy. Multivariable Cox proportional hazards regression models were applied. Results We found 187 cases (126 women) of severe‐NPDR/PDR during a median follow‐up period of 12.7 years; the corresponding incidence rate was 13.6 per 1,000 person‐years. Being overweight (hazard ratio [HR], 95% confidence interval [CI] 0.60, 0.39–0.92) and obese (HR 0.48, 95% CI 0.27–0.83) were associated with lower risk, whereas being smoker (HR 1.75, 95% CI 1.12–2.74), having fasting plasma glucose levels 7.22–10.0 mmol/L (HR 2.81, 95% CI 1.70–4.62), fasting plasma glucose ≥10 mmol/L (HR 5.87, 95% CI 3.67–9.41), taking glucose‐lowering medications (HR 2.58, 95% CI 1.87–3.56), prehypertension status (HR 1.65, 95% CI 1.05–2.58) and newly diagnosed hypertension (HR 1.96, 95% CI 1.06–3.65) increased the risk of severe‐NPDR/PDR. Among newly diagnosed diabetes patients, being male was associated with a 59% lower risk of severe‐NPDR/PDR (HR 0.41, 95% CI 0.21–0.79). Furthermore, patients who had an intermediate level of education (6–12 years) had a higher risk of developing PDR (HR 1.86, 95% CI 1.05–3.30) compared with those who had
- Subjects :
- Adult
Male
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
Iran
Overweight
Lower risk
Diseases of the endocrine glands. Clinical endocrinology
Prehypertension
Young Adult
Risk Factors
Internal medicine
Diabetes mellitus
Internal Medicine
medicine
Proliferative diabetic retinopathy
Humans
Diabetic Retinopathy
business.industry
Incidence
Incidence (epidemiology)
Hazard ratio
General Medicine
Diabetic retinopathy
Visual impairment
RC648-665
medicine.disease
Lipids
eye diseases
Glucose
Blood pressure
Diabetes Mellitus, Type 2
Microvascular complication
Female
medicine.symptom
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 20401124 and 20401116
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Journal of Diabetes Investigation
- Accession number :
- edsair.doi.dedup.....ee22f809e27317e75878072ff391bff1