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Formin defines a large family of morphoregulatory genes and functions in establishment of the polarising region
- Source :
- Cell and tissue research. 296(1)
- Publication Year :
- 1999
-
Abstract
- Formin was originally isolated as the gene affected by the murine limb deformity (ld) mutations, which disrupt the epithelial-mesenchymal interactions regulating patterning of the vertebrate limb autopod. More recently, a rapidly growing number of genes with similarity to formin have been isolated from many different species including fungi and plants. Genetic and biochemical analysis shows that formin family members function in cellular processes regulating either cytokinesis and/or cell polarisation. Another common feature among formin family members is their requirement in morphogenetic processes such as budding and conjugation of yeast, establishment of Drosophila oocyte polarity and vertebrate limb pattern formation. Vertebrate formins are predominantly nuclear proteins which control polarising activity in limb buds through establishment of the SHH/FGF-4 feedback loop. Formin acts in the limb bud mesenchyme to induce apical ectodermal ridge (AER) differentiation and FGF-4 expression in the posterior AER compartment. Finally, disruption of the epithelial-mesenchymal interactions controlling induction of metanephric kidneys in ld mutant embryos indicates that formin might function more generally in transduction of morphogenetic signals during embryonic pattern formation.
- Subjects :
- Apical ectodermal ridge
Fetal Proteins
Histology
Mesenchyme
Mutant
Molecular Sequence Data
Limb Deformities, Congenital
Formins
macromolecular substances
Pathology and Forensic Medicine
Evolution, Molecular
Limb bud
Mice
medicine
Morphogenesis
Animals
Humans
Amino Acid Sequence
Phylogeny
Body Patterning
Genetics
biology
Sequence Homology, Amino Acid
fungi
Microfilament Proteins
Nuclear Proteins
Extremities
Cell Biology
Embryonic stem cell
medicine.anatomical_structure
Zone of polarizing activity
Multigene Family
biology.protein
Sequence Alignment
Cytokinesis
Signal Transduction
Transcription Factors
Subjects
Details
- ISSN :
- 0302766X
- Volume :
- 296
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Cell and tissue research
- Accession number :
- edsair.doi.dedup.....ee5637a8fca4fa506bb5a574171b1fcd