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New developments on the TNFα-mediated signalling pathways
- Source :
- Bioscience Reports. 31:63-76
- Publication Year :
- 2010
- Publisher :
- Portland Press Ltd., 2010.
-
Abstract
- TNFα (tumour necrosis factor α) is an extensively studied pleiotropic cytokine associated with the pathogenesis of a variety of inflammatory diseases. It elicits a wide spectrum of cellular responses which mediates and regulates inflammation, immune response, cell survival, proliferation and apoptosis. TNFα initiates its responses by binding to its receptors. TNFα-induced effector responses are mediated by the actions and interactions among the various intracellular signalling mediators in the cell. TNFα induces both survival and apoptotic signal in a TRADD (TNF receptor-associated DD)-dependent and -independent way. The signals are further transduced via a variety of signalling mediators, including caspases, MAPKs (mitogen-activated protein kinases), phospholipid mediators and miRNA/miR (microRNA), whose roles in specific functional responses is not fully understood. Elucidating the complexity and cross talks among signalling mediators involved in the TNFα-mediated responses will certainly aid in the identification of molecular targets, which can potentially lead to the development of novel therapeutics to treat TNFα-associated disorders and in dampening inflammation.
- Subjects :
- medicine.medical_treatment
Biophysics
Inflammation
Cell Communication
Ligands
Biochemistry
medicine
Animals
Humans
Receptor
Molecular Biology
Caspase
biology
Tumor Necrosis Factor-alpha
Kinase
Effector
Cell Biology
TRADD
Cell biology
Cytokine
biology.protein
Tumor necrosis factor alpha
Inflammation Mediators
medicine.symptom
Signal Transduction
Subjects
Details
- ISSN :
- 15734935 and 01448463
- Volume :
- 31
- Database :
- OpenAIRE
- Journal :
- Bioscience Reports
- Accession number :
- edsair.doi.dedup.....ee6789028d8e48fed5cd17540fac3344