Back to Search
Start Over
Structural proteomics: the potential of high-throughput structure determination
- Source :
- Trends in Microbiology. 10:s27-s31
- Publication Year :
- 2002
- Publisher :
- Elsevier BV, 2002.
-
Abstract
- The pharmaceutical industry has embraced genomics as a means to identify new biological targets for target-based drug discovery approaches. Now, genomics is driving a substantial effort in protein structure determination and structure prediction. These structures will provide the opportunity to undertake structure-guided drug discovery programs in the search for new classes of broad-spectrum antibiotics. In addition, these structures could provide structure-based criteria to prioritize certain targets for focused drug discovery programs.
- Subjects :
- Proteomics
Microbiology (medical)
Protein Conformation
Genomics
Computational biology
Biology
Peptide Mapping
Microbiology
Imaging, Three-Dimensional
Anti-Infective Agents
Virology
Structural proteomics
Technology, Pharmaceutical
Throughput (business)
Pharmaceutical industry
Structure (mathematical logic)
Crystallography
Molecular Structure
business.industry
Drug discovery
Peptide mapping
Anti-Bacterial Agents
Biotechnology
Infectious Diseases
Drug Design
business
Subjects
Details
- ISSN :
- 0966842X
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Trends in Microbiology
- Accession number :
- edsair.doi.dedup.....ee773421e855c5df2cc9ea686dd9f219
- Full Text :
- https://doi.org/10.1016/s0966-842x(02)02443-5