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Age-related alterations in tanycytes of the mediobasal hypothalamus of the male rat
- Source :
- Neurobiology of Aging. 16:77-83
- Publication Year :
- 1995
- Publisher :
- Elsevier BV, 1995.
-
Abstract
- By means of semiquantitative immunocytochemistry, possible age-related changes in dopamine and cyclic AMP-regulated phosphoprotein mr 32 (DARPP-32) and glial fibrillary acidic protein (GFAP) immunoreactivities (IR) were investigated in tanycytes of the arcuate nucleus. These two markers showed opposite changes during aging. DARPP-32 IR decreased by around 70%, whereas GFAP IR increased by around 300% in 24-month-old vs. 3-month-old rats. These changes were accompanied by a progressive loss in the number of tanycytes, measured by counting of their long processes in the arcuate nucleus. No significant age-related change was observed either in GFAP IR in astrocytic populations of the mediobasal hypothalamus or in tyrosine hydroxylase IR in dopaminergic neurons of the dorsal arcuate nucleus. These observations indicate that the tanycytic population of the arcuate nucleus undergoes important modifications during aging, which include cell loss, impairment in the intracellular signalling cascade linked to DARPP-32, and hypertrophy. These changes may be related to the alterations in the neuroendocrine systems known to occur during aging.
- Subjects :
- Male
Dopamine and cAMP-Regulated Phosphoprotein 32
Aging
medicine.medical_specialty
Tyrosine 3-Monooxygenase
Population
Hypothalamus, Middle
Nerve Tissue Proteins
Glial fibrillary acidic protein
Rats, Sprague-Dawley
Astroglia
Arcuate nucleus
Dopamine
Internal medicine
Glial Fibrillary Acidic Protein
Image Processing, Computer-Assisted
medicine
Animals
education
education.field_of_study
Tanycytes
Dopamine- and cAMP-regulated phosphoprotein mr 32
Computer-assisted image analysis
Rat
Tyrosine hydroxylase
biology
Tanycyte
General Neuroscience
Dopaminergic
Arcuate Nucleus of Hypothalamus
Phosphoproteins
Immunohistochemistry
Rats
medicine.anatomical_structure
Endocrinology
Hypothalamus
Astrocytes
biology.protein
Neurology (clinical)
Geriatrics and Gerontology
Paraventricular Hypothalamic Nucleus
Developmental Biology
medicine.drug
Subjects
Details
- ISSN :
- 01974580
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- Neurobiology of Aging
- Accession number :
- edsair.doi.dedup.....ee7a011169d1675f348c1165a3d9cb3b