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Current smoking with or without chronic bronchitis is independently associated with goblet cell hyperplasia in healthy smokers and COPD subjects
- Source :
- Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020), Scientific Reports
- Publication Year :
- 2020
- Publisher :
- Nature Publishing Group, 2020.
-
Abstract
- COPD, chronic bronchitis (CB) and active smoking have all been associated with goblet cell hyperplasia (GCH) in small studies. Active smoking is strongly associated with CB, but there is a disconnect between CB clinical symptoms and pathology. Chronic cough and sputum production poorly correlate with the presence of GCH or COPD. We hypothesized that the primary determinant of GCH in ever smokers with or without airflow obstruction is active smoking. Goblet Cell Density (GCD) was measured in 71 current or former smokers [32 subjects without COPD and 39 COPD subjects]. Endobronchial mucosal biopsies were stained with Periodic Acid Schiff-Alcian Blue, and GCD was measured as number of goblet cells/mm basement membrane. GCD was divided into tertiles based on log10 transformed values. Log10GCD was greater in current smokers compared to former smokers. Those with classically defined CB or SGRQ defined CB had a greater log10 GCD compared to those without CB. Current smoking was independently associated with tertile 3 (high log10GCD) whereas CB was not in multivariable regression when adjusting for lung function and demographics. These results suggest that GCH is induced by active smoke exposure and does not necessarily correlate with the clinical symptoms of CB.
- Subjects :
- Male
Chronic bronchitis
medicine.medical_specialty
Goblet cell hyperplasia
lcsh:Medicine
Sputum Production
Gastroenterology
Article
Pulmonary Disease, Chronic Obstructive
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Humans
Prospective Studies
030212 general & internal medicine
lcsh:Science
Lung function
Aged
COPD
Goblet cell
Hyperplasia
Smokers
Multidisciplinary
business.industry
Chronic obstructive pulmonary disease
Smoking
lcsh:R
Middle Aged
Translational research
Former Smoker
medicine.disease
respiratory tract diseases
Bronchitis, Chronic
Chronic cough
Logistic Models
medicine.anatomical_structure
030228 respiratory system
Female
lcsh:Q
Goblet Cells
medicine.symptom
business
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 10
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....ee7ce6644ce81017abd5aa8d45f98c8a