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Effects of SARS-CoV-2 Alpha, Beta, and Delta variants, age, vaccination, and prior infection on infectiousness of SARS-CoV-2 infections
- Source :
- Qassim, S H, Hasan, M R, Tang, P, Chemaitelly, H, Ayoub, H H, Yassine, H M, Al-Khatib, H A, Smatti, M K, Abdul-Rahim, H F, Nasrallah, G K, Al-Kuwari, M G, Al-Khal, A, Coyle, P, Gillani, I, Kaleeckal, A H, Shaik, R M, Latif, A N, Al-Kuwari, E, Jeremijenko, A, Butt, A A, Bertollini, R, Al-Romaihi, H E, Al-Thani, M H & Abu-Raddad, L J 2022, ' Effects of SARS-CoV-2 Alpha, Beta, and Delta variants, age, vaccination, and prior infection on infectiousness of SARS-CoV-2 infections ', Frontiers in Immunology, vol. 13, 984784 . https://doi.org/10.3389/fimmu.2022.984784
- Publication Year :
- 2022
-
Abstract
- In 2021, Qatar experienced considerable incidence of SARS-CoV-2 infection that was dominated sequentially by the Alpha, Beta, and Delta variants. Using the cycle threshold (Ct) value of an RT-qPCR-positive test to proxy the inverse of infectiousness, we investigated infectiousness of SARS-CoV-2 infections by variant, age, sex, vaccination status, prior infection status, and reason for testing in a random sample of 18,355 RT-qPCR-genotyped infections. Regression analyses were conducted to estimate associations with the Ct value of RT-qPCR-positive tests. Compared to Beta infections, Alpha and Delta infections demonstrated 2.56 higher Ct cycles (95% CI: 2.35-2.78), and 4.92 fewer cycles (95% CI: 4.67-5.16), respectively. The Ct value declined gradually with age and was especially high for children
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Qassim, S H, Hasan, M R, Tang, P, Chemaitelly, H, Ayoub, H H, Yassine, H M, Al-Khatib, H A, Smatti, M K, Abdul-Rahim, H F, Nasrallah, G K, Al-Kuwari, M G, Al-Khal, A, Coyle, P, Gillani, I, Kaleeckal, A H, Shaik, R M, Latif, A N, Al-Kuwari, E, Jeremijenko, A, Butt, A A, Bertollini, R, Al-Romaihi, H E, Al-Thani, M H & Abu-Raddad, L J 2022, ' Effects of SARS-CoV-2 Alpha, Beta, and Delta variants, age, vaccination, and prior infection on infectiousness of SARS-CoV-2 infections ', Frontiers in Immunology, vol. 13, 984784 . https://doi.org/10.3389/fimmu.2022.984784
- Accession number :
- edsair.doi.dedup.....ee8288a1ef236361ddb37c573775ea52
- Full Text :
- https://doi.org/10.3389/fimmu.2022.984784