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Serum 25-Hydroxyvitamin D Levels in Relation to Lung Function and Exhaled Nitric Oxide in Children
- Source :
- The Journal of Pediatrics. 165:1098-1103.e1
- Publication Year :
- 2014
- Publisher :
- Elsevier BV, 2014.
-
Abstract
- To investigate the relationship of vitamin D status with lung function and fraction of exhaled nitric oxide (FeNO) in a population sample of children.A total of 1315 children aged 5-18 years were evaluated using serum 25-hydroxyvitamin D [25(OH)D] levels, spirometry, a single-breath online FeNO measurement, and questionnaires.After adjusting for confounders, the mean forced vital capacity was 53.4 mL (SE, 26.5 mL; P = .045), and the mean forced expiratory volume in 1 second was 48.2 mL (SE, 23.6 mL; P = .042) lower for children with insufficient serum 25(OH)D levels (20-29.9 ng/mL) compared with those with sufficient 25(OH)D levels (≥30 ng/mL). The mean difference between children with deficient (20 ng/mL) and sufficient levels of serum 25(OH)D was 81.9 mL (SE, 26.7 mL; P = .002) for forced vital capacity and 55.2 mL (SE, 23.7 mL; P = .020) for forced expiratory volume in 1 second. There was no significant association between serum 25(OH)D levels and FeNO after adjusting for confounders.Our results demonstrate a significant relationship between insufficient serum vitamin D levels and worse lung function in children in the community with a suggested dose-response effect. Our findings also suggest that vitamin D status is not a significant determinant of FeNO in children in the general population.
- Subjects :
- Male
Spirometry
medicine.medical_specialty
Vital capacity
Adolescent
Vital Capacity
Population
Nitric Oxide
Gastroenterology
Nitric oxide
Cohort Studies
Young Adult
FEV1/FVC ratio
chemistry.chemical_compound
Internal medicine
medicine
Vitamin D and neurology
Humans
Vitamin D
Child
education
Lung
education.field_of_study
medicine.diagnostic_test
business.industry
Breath Tests
chemistry
Child, Preschool
Anesthesia
Multivariate Analysis
Pediatrics, Perinatology and Child Health
Exhaled nitric oxide
Regression Analysis
Female
business
Body mass index
Subjects
Details
- ISSN :
- 00223476
- Volume :
- 165
- Database :
- OpenAIRE
- Journal :
- The Journal of Pediatrics
- Accession number :
- edsair.doi.dedup.....ee944c2cb644780f44bd9a004e5ee446