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Prescription drugs associated with false-positive results when using faecal immunochemical tests for colorectal cancer screening
- Source :
- Digestive and Liver Disease. 48:1249-1254
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- Background The most common side effect in population screening programmes is a false-positive result which leads to unnecessary risks and costs. Aims To identify factors associated with false-positive results in a colorectal cancer screening programme with the faecal immunochemical test (FIT). Methods Cross-sectional study of 472 participants with a positive FIT who underwent colonoscopy for confirmation of diagnosis between 2013 and 2014. A false-positive result was defined as having a positive FIT (≥20 μg haemoglobin per gram of faeces) and follow-up colonoscopy without intermediate/high-risk lesions or cancer. Results Women showed a two-fold increased likelihood of a false-positive result compared with men (adjusted OR, 2.3; 95%CI, 1.5–3.4), but no female-specific factor was identified. The other variables associated with a false-positive result were successive screening (adjusted OR, 1.5; 95%CI, 1.0–2.2), anal disorders (adjusted OR, 3.1; 95%CI, 2.1–4.5) and the use of proton pump inhibitors (adjusted OR, 1.8; 95%CI, 1.1–2.9). Successive screening and proton pump inhibitor use were associated with FP in men. None of the other drugs were related to a false-positive FIT. Conclusion Concurrent use of proton pump inhibitors at the time of FIT might increase the likelihood of a false-positive result. Further investigation is needed to determine whether discontinuing them could decrease the false-positive rate.
- Subjects :
- Male
medicine.medical_specialty
Prescription Drugs
Multivariate analysis
Side effect
medicine.drug_class
Cross-sectional study
Proton-pump inhibitor
Colonoscopy
Gastroenterology
Feces
Hemoglobins
03 medical and health sciences
0302 clinical medicine
Risk Factors
Internal medicine
medicine
Humans
Mass Screening
False Positive Reactions
Medical prescription
Early Detection of Cancer
Mass screening
Aged
Anus Diseases
Hepatology
medicine.diagnostic_test
business.industry
nutritional and metabolic diseases
Cancer
Proton Pump Inhibitors
Middle Aged
medicine.disease
Cross-Sectional Studies
Logistic Models
Spain
Occult Blood
030220 oncology & carcinogenesis
Multivariate Analysis
Female
030211 gastroenterology & hepatology
Colorectal Neoplasms
business
Subjects
Details
- ISSN :
- 15908658
- Volume :
- 48
- Database :
- OpenAIRE
- Journal :
- Digestive and Liver Disease
- Accession number :
- edsair.doi.dedup.....eec9572ce53e2bd47ec7839b8afc0819