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Quantitative Morphological Studies of Aging Changes in the Kidney of the Lewis Rat
- Source :
- Kidney and Blood Pressure Research. 7:176-184
- Publication Year :
- 1984
- Publisher :
- S. Karger AG, 1984.
-
Abstract
- Spontaneous aging changes in the kidneys of the rat have been previously described. In the Lewis strain, we performed semiquantitative studies of kidney histology and quantitative studies of glomerular basement membrane thickness and mesangial area in animals aged 6–30 months. There is a progressive increase in glomerular basement membrane thickness and mesangial area throughout the life of the rat. Spontaneous glomerulosclerosis in the Lewis rat does not appear to be as extensive as in other strains. The importance of spontaneous glomerulosclerosis in studies of induced kidney disease is emphasized.
- Subjects :
- Male
Aging
medicine.medical_specialty
Kidney Glomerulus
Strain (injury)
Biology
Kidney
Basement Membrane
Kidney histology
Internal medicine
medicine
Animals
Glomerulosclerosis, Focal Segmental
urogenital system
Glomerulosclerosis
General Medicine
medicine.disease
biology.organism_classification
Glomerular Mesangium
Rats
Endocrinology
medicine.anatomical_structure
Rats, Inbred Lew
Nephrology
Glomerula
Cardiology and Cardiovascular Medicine
Kidney disease
Subjects
Details
- ISSN :
- 14230143 and 14204096
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Kidney and Blood Pressure Research
- Accession number :
- edsair.doi.dedup.....eecbb7ef5f6d68dc8021317cfcd04dc3