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The potential therapeutic and prognostic impacts of the c‐MET/HGF signaling pathway in colorectal cancer
- Source :
- IUBMB Life.
- Publication Year :
- 2019
- Publisher :
- Wiley, 2019.
-
Abstract
- Colorectal cancer (CRC) is the third most common cancer and a common cause of cancer-related mortality globally. In spite of the improvements in the early diagnosis of CRC, approximately one-third of patients develop metastasis and then have a very poor survival rate. The mesenchymal-epithelial transition factor (c-MET) is a tyrosine kinase cell surface receptor activated by hepatocyte growth factor (HGF). Activation of c-MET/HGF signaling pathway regulates a variety of biological processes including cell motility, cell proliferation, angiogenesis, the epithelial-to-mesenchymal transition, and the development and progression of cancer cells. Recent studies have suggested that the c-MET/HGF signaling pathway is involved in the carcinogenesis of CRC. In this review, we summarize the main findings of recent studies investigating the role of c-MET/HGF signaling pathway in CRC and the potential of the c-MET/HGF signaling pathways in the diagnosis and treatment of CRC. © 2019 IUBMB Life, 2019.
- Subjects :
- 0301 basic medicine
Epithelial-Mesenchymal Transition
C-Met
Colorectal cancer
Angiogenesis
Clinical Biochemistry
Antineoplastic Agents
medicine.disease_cause
Biochemistry
Metastasis
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Cell Movement
Genetics
medicine
Humans
Molecular Biology
Neovascularization, Pathologic
Hepatocyte Growth Factor
business.industry
Cancer
Cell Biology
Proto-Oncogene Proteins c-met
Prognosis
medicine.disease
030104 developmental biology
chemistry
030220 oncology & carcinogenesis
Cancer cell
Cancer research
Hepatocyte growth factor
Colorectal Neoplasms
Carcinogenesis
business
Signal Transduction
medicine.drug
Subjects
Details
- ISSN :
- 15216551 and 15216543
- Database :
- OpenAIRE
- Journal :
- IUBMB Life
- Accession number :
- edsair.doi.dedup.....eed7d271dd68a3e0db4ef904a502b171