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Polypeptide N-acetylgalactosaminyl transferase 3 independently predicts high-grade tumours and poor prognosis in patients with renal cell carcinomas
- Source :
- British Journal of Cancer
- Publication Year :
- 2013
- Publisher :
- Nature Publishing Group, 2013.
-
Abstract
- Background: The polypeptide N-acetylgalactosaminyltransferases (GalNAc-Ts) family of enzymes regulates the initial steps of mucin-type O-glycosylation. N-acetylgalactosaminyltransferases might show novel patterns of GalNAc-T glycosylation on tumour-derived proteins, which could influence cancer biology, but its mechanisms are unclear. We investigated the association of GalNAc-T3 and -T6 expressions with clinicopathological features and prognoses of patients with renal cell carcinomas (RCCs). Methods: Expressions of GalNAc-T3/6 and cell-adhesion molecules were analysed immunohistochemically in 254 paraffin-embedded tumour samples of patients with RCC. Results: Of 138 GalNAc-T3+ cases, 46 revealed significant co-expression with GalNAc-T6. N-acetylgalactosaminyltransferases-3+ expression showed a close relationship to poor clinical performance and large tumour size, or pathologically high Fuhrman's grading, and presence of vascular invasion and necrosis. The GalNAc-T3-positivity potentially suppressed adhesive effects with a significantly low β-catenin expression. Univariate and multivariate analyses showed the GalNAc-T3+ group, but not the GalNAc-T6+ group, to have significantly worse survival rates. Conclusion: N-acetylgalactosaminyltransferases-3 expression independently predicts high-grade tumour and poor prognosis in patients with RCC, and may offer a therapeutic target against RCC.
- Subjects :
- Adult
Male
Cancer Research
Pathology
medicine.medical_specialty
Poor prognosis
renal cell carcinoma
Cell
Biology
Cohort Studies
Cell Line, Tumor
parasitic diseases
medicine
Carcinoma
Biomarkers, Tumor
Transferase
Humans
In patient
vascular invasion
Molecular Diagnostics
Carcinoma, Renal Cell
Aged
Retrospective Studies
Aged, 80 and over
Middle Aged
medicine.disease
Prognosis
Kidney Neoplasms
carbohydrates (lipids)
medicine.anatomical_structure
Oncology
Cell culture
GalNAc-T6
Cancer research
N-Acetylgalactosaminyltransferases
lipids (amino acids, peptides, and proteins)
GalNAc-T3
Female
Neoplasm Grading
Subjects
Details
- Language :
- English
- ISSN :
- 15321827 and 00070920
- Volume :
- 109
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- British Journal of Cancer
- Accession number :
- edsair.doi.dedup.....eef2fa6872ffae470f362e67934bfd4f