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Analysis of tetracycline antibiotics and their common impurities by high-performance liquid chromatography using a polymeric column
Analysis of tetracycline antibiotics and their common impurities by high-performance liquid chromatography using a polymeric column
- Source :
- Journal of pharmaceutical and biomedical analysis. 6(6-8)
- Publication Year :
- 1987
-
Abstract
- The chromatographic separation of tetracycline, oxytetracycline, 6-demethyl-chlortetracycline, methacycline and minocycline, and the common impurities of tetracycline, oxytetracycline and chlortetracycline has been optimised on a Hamilton PRP-1 column using citrate-phosphate buffer with propan-2-ol and tetrahydrofuran as organic modifiers. Column efficiency was approximately doubled by the inclusion of 1% v/v dichloromethane in the mobile phase.
- Subjects :
- Chlortetracycline
Methacycline
Chromatography
Tetracycline
medicine.drug_class
Chemistry
Clinical Biochemistry
Tetracycline antibiotics
Pharmaceutical Science
Oxytetracycline
High-performance liquid chromatography
Analytical Chemistry
chemistry.chemical_compound
Drug Discovery
medicine
Spectroscopy
Tetrahydrofuran
medicine.drug
Dichloromethane
Subjects
Details
- ISSN :
- 07317085
- Volume :
- 6
- Issue :
- 6-8
- Database :
- OpenAIRE
- Journal :
- Journal of pharmaceutical and biomedical analysis
- Accession number :
- edsair.doi.dedup.....eef667bc5df20e869886506d605a863d