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Analysis of tetracycline antibiotics and their common impurities by high-performance liquid chromatography using a polymeric column

Analysis of tetracycline antibiotics and their common impurities by high-performance liquid chromatography using a polymeric column

Authors :
T.M. Jefferies
A. Yasin
Source :
Journal of pharmaceutical and biomedical analysis. 6(6-8)
Publication Year :
1987

Abstract

The chromatographic separation of tetracycline, oxytetracycline, 6-demethyl-chlortetracycline, methacycline and minocycline, and the common impurities of tetracycline, oxytetracycline and chlortetracycline has been optimised on a Hamilton PRP-1 column using citrate-phosphate buffer with propan-2-ol and tetrahydrofuran as organic modifiers. Column efficiency was approximately doubled by the inclusion of 1% v/v dichloromethane in the mobile phase.

Details

ISSN :
07317085
Volume :
6
Issue :
6-8
Database :
OpenAIRE
Journal :
Journal of pharmaceutical and biomedical analysis
Accession number :
edsair.doi.dedup.....eef667bc5df20e869886506d605a863d