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Whole blood microRNA markers are associated with acute respiratory distress syndrome
- Source :
- Intensive Care Medicine Experimental, Vol 5, Iss 1, Pp 1-12 (2017), Intensive Care Medicine Experimental
- Publication Year :
- 2017
- Publisher :
- Springer Science and Business Media LLC, 2017.
-
Abstract
- Background MicroRNAs (miRNAs) can play important roles in inflammation and infection, which are common manifestations of acute respiratory distress syndrome (ARDS). We assessed if whole blood miRNAs were potential diagnostic biomarkers for human ARDS. Methods This nested case-control study (N = 530) examined a cohort of ARDS patients and critically ill at-risk controls. Whole blood miRNA profiles and logistic regression analyses identified miRNAs correlated with ARDS. Stratification analysis also assessed selected miRNA markers for their role in sepsis and pneumonia associated with ARDS. Receiver operating characteristic (ROC) analysis evaluated miRNA diagnostic performance, along with Lung Injury Prediction Score (LIPS). Results Statistical analyses were performed on 294 miRNAs, selected from 754 miRNAs after quality control screening. Logistic regression identified 22 miRNAs from a 156-patient discovery cohort as potential risk or protective markers of ARDS. Three miRNAs—miR-181a, miR-92a, and miR-424—from the discovery cohort remained significantly associated with ARDS in a 373-patient independent validation cohort (FDR q
- Subjects :
- 0301 basic medicine
Oncology
Pathology
medicine.medical_specialty
ARDS
Lung injury
Critical Care and Intensive Care Medicine
Logistic regression
Sepsis
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Whole blood
Receiver operating characteristic
business.industry
Research
lcsh:Medical emergencies. Critical care. Intensive care. First aid
MicroRNA
lcsh:RC86-88.9
medicine.disease
3. Good health
030104 developmental biology
030220 oncology & carcinogenesis
Cohort
Biomarker (medicine)
LIPS
business
Subjects
Details
- ISSN :
- 2197425X
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- Intensive Care Medicine Experimental
- Accession number :
- edsair.doi.dedup.....eef7d5e34106c5ba299722436e6960d5