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Prescription opioid misusers exhibit blunted parasympathetic regulation during inhibitory control challenge
- Source :
- Psychopharmacology (Berl)
- Publication Year :
- 2020
-
Abstract
- RATIONALE: Among opioid-treated chronic pain patients, response inhibition deficits in emotional contexts may contribute to opioid misuse. OBJECTIVES: Using high frequency heart rate variability (HF-HRV) to index impaired response inhibition, we examined associations between opioid misuse and response inhibition in emotional and neutral contexts in a sample of opioid-treated chronic pain patients. METHOD: Chronic pain patients taking opioid analgesics (N = 97) for ≥ 90 days completed an Emotional Go/NoGo Task that presented an inhibitory control challenge in the context of neutral, opioid, negative affective, and positive affective background images while HF-HRV was recorded. Opioid misuse and craving were assessed. Using a validated cut-point on the Current Opioid Misuse Measure, participants were classified as opioid misusers or non-misusers. Opioid misuse was examined as a predictor of behavioral and HF-HRV metrics of response inhibition. RESULTS: Negative affective and opioid images elicited more errors of commission (p = .002, η(2)(partial) = .16) and slowed reaction times (p = .045, η(2)(partial) = .09) than neutral and positive affective images, respectively. Though no between-groups behavioral differences were observed on the task, opioid misusers exhibited significantly blunted phasic HF-HRV during the task relative to non-misusers (p = .027, η(2)(partial) = .11). HF-HRV during the task was significantly inversely associated with opioid craving. It was not clear whether these autonomic findings reflected a durable phenotypic difference between groups or between-groups differences in opioid dosing and withdrawal. CONCLUSION: Reduced parasympathetic regulation during inhibitory control challenge may indicate heightened opioid misuse risk among opioid-treated chronic pain patients.
- Subjects :
- Adult
Male
medicine.medical_specialty
Prescription Drugs
Emotions
Context (language use)
Craving
Autonomic Nervous System
Article
03 medical and health sciences
0302 clinical medicine
Heart Rate
Internal medicine
Inhibitory control
medicine
Heart rate variability
Humans
Pharmacology
business.industry
Chronic pain
Cognition
Middle Aged
medicine.disease
Opioid-Related Disorders
030227 psychiatry
Analgesics, Opioid
Opioid
Prescription opioid
Female
medicine.symptom
Chronic Pain
business
030217 neurology & neurosurgery
medicine.drug
Subjects
Details
- ISSN :
- 14322072
- Volume :
- 238
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Psychopharmacology
- Accession number :
- edsair.doi.dedup.....eefe4b1da57b787cbacbb4d02d4c8130