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SOCS Proteins Participate in the Regulation of Innate Immune Response Caused by Viruses
- Source :
- Frontiers in Immunology, Frontiers in Immunology, Vol 11 (2020)
- Publication Year :
- 2020
- Publisher :
- Frontiers Media SA, 2020.
-
Abstract
- The host immune system has multiple innate immune receptors that can identify, distinguish and react to viral infections. In innate immune response, the host recognizes pathogen-associated molecular patterns (PAMP) in nucleic acids or viral proteins through pathogen recognition receptors (PRRs), especially toll-like receptors (TLRs) and induces immune cells or infected cells to produce type I Interferons (IFN-I) and pro-inflammatory cytokines, thus when the virus invades the host, innate immunity is the earliest immune mechanism. Besides, cytokine-mediated cell communication is necessary for the proper regulation of immune responses. Therefore, the appropriate activation of innate immunity is necessary for the normal life activities of cells. The suppressor of the cytokine signaling proteins (SOCS) family is one of the main regulators of the innate immune response induced by microbial pathogens. They mainly participate in the negative feedback regulation of cytokine signal transduction through Janus kinase signal transducer and transcriptional activator (JAK/STAT) and other signal pathways. Taken together, this paper reviews the SOCS proteins structures and the function of each domain, as well as the latest knowledge of the role of SOCS proteins in innate immune caused by viral infections and the mechanisms by which SOCS proteins assist viruses to escape host innate immunity. Finally, we discuss potential values of these proteins in future targeted therapies.
- Subjects :
- lcsh:Immunologic diseases. Allergy
0301 basic medicine
Cell signaling
animal diseases
medicine.medical_treatment
Immunology
Suppressor of Cytokine Signaling Proteins
chemical and pharmacologic phenomena
Review
virus
Biology
Virus
stat
Immunomodulation
03 medical and health sciences
0302 clinical medicine
Immune system
TLR
cytokine
medicine
Animals
Humans
Immunology and Allergy
Protein Interaction Domains and Motifs
Receptor
Innate immune system
Disease Management
biochemical phenomena, metabolism, and nutrition
Immunity, Innate
Cell biology
MicroRNAs
030104 developmental biology
Cytokine
Gene Expression Regulation
Virus Diseases
Host-Pathogen Interactions
Viruses
bacteria
innate immune
lcsh:RC581-607
Carrier Proteins
Janus kinase
Protein Binding
Signal Transduction
030215 immunology
Subjects
Details
- ISSN :
- 16643224
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Frontiers in Immunology
- Accession number :
- edsair.doi.dedup.....eeff315f4634fbae1d4282b062e3f040