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A systems model of phosphorylation for inflammatory signaling events
- Source :
- PLoS ONE, Vol 9, Iss 10, p e110913 (2014), PLoS ONE
- Publication Year :
- 2014
- Publisher :
- Public Library of Science (PLoS), 2014.
-
Abstract
- Phosphorylation is a fundamental biochemical reaction that modulates protein activity in cells. While a single phosphorylation event is relatively easy to understand, multisite phosphorylation requires systems approaches for deeper elucidation of the underlying molecular mechanisms. In this paper we develop a mechanistic model for single- and multi-site phosphorylation. The proposed model is compared with previously reported studies. We compare the predictions of our model with experiments published in the literature in the context of inflammatory signaling events in order to provide a mechanistic description of the multisite phosphorylation-mediated regulation of Signal Transducer and Activator of Transcription 3 (STAT3) and Interferon Regulatory Factor 5 (IRF-5) proteins. The presented model makes crucial predictions for transcription factor phosphorylation events in the immune system. The model proposes potential mechanisms for T cell phenotype switching and production of cytokines. This study also provides a generic framework for the better understanding of a large number of multisite phosphorylation-regulated biochemical circuits.
- Subjects :
- STAT3 Transcription Factor
inorganic chemicals
Biophysical Simulations
Computer and Information Sciences
T-Lymphocytes
Immunology
Biophysics
lcsh:Medicine
Context (language use)
Computational biology
macromolecular substances
Biology
Bioinformatics
Biochemistry
Systems Science
Biochemical Simulations
Humans
Phosphorylation
STAT3
lcsh:Science
Transcription factor
Immune Response
Theoretical Biology
Inflammation
Multidisciplinary
Systems Biology
lcsh:R
Immunity
Biology and Life Sciences
Computational Biology
Cell Differentiation
Interferon Regulatory Factors
STAT protein
biology.protein
Cytokines
bacteria
Synthetic Biology
lcsh:Q
Signal transduction
Interferon regulatory factors
Research Article
Signal Transduction
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 9
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....ef039087cb088f630fab156b9964c140