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Reverse remodeling of pulmonary arteries by high-dose prostaglandin I2 therapy: A case report
- Publication Year :
- 2014
- Publisher :
- Japanese College of Cardiology, 2014.
-
Abstract
- Idiopathic pulmonary arterial hypertension (IPAH) is characterized by pulmonary vascular remodeling. We have reported that high-dose prostaglandin I 2 (PGI 2 ) therapy markedly improved hemodynamics in IPAH patients and that PGI 2 induced apoptosis of pulmonary artery smooth muscle cells obtained from IPAH patients. PGI 2 is thought to have reverse remodeling effects, although it has not been histologically confirmed. In a case series, we examined the reverse pulmonary vascular remodeling effects of PGI 2 in lung tissues obtained from an IPAH patient treated with high-dose PGI 2 and an IPAH patient not treated with PGI 2 . Apoptotic cells were detected in small pulmonary arteries of the IPAH patient treated with high-dose PGI 2 but not in those from the IPAH patient not treated with PGI 2 . Media of peripheral pulmonary arteries were thick in the IPAH patient not treated with PGI 2 . On the other hand, media of peripheral pulmonary arteries were thin in the IPAH patient treated with high-dose PGI 2 . The single case report suggested that high-dose PGI 2 therapy has the potential for reverse pulmonary vascular remodeling by induction of apoptosis and reduction of medial hypertrophy. Accumulation of cases is needed for the application to generalized effect of high-dose PGI 2 . Learning objective: Reverse pulmonary vascular remodeling would provide further improvement in patients with IPAH. High-dose PGI 2 therapy has the potential for reverse pulmonary vascular remodeling in patients with IPAH.>
- Subjects :
- medicine.medical_specialty
Pathology
Prostaglandin
Hemodynamics
Apoptosis
Article
chemistry.chemical_compound
Internal medicine
medicine.artery
Medial hypertrophy
Medicine
In patient
High-dose epoprostenol
Reverse remodeling
Idiopathic pulmonary arterial hypertension
Lung
business.industry
Remodeling
Peripheral
medicine.anatomical_structure
chemistry
Pulmonary artery
Cardiology
cardiovascular system
lipids (amino acids, peptides, and proteins)
Cardiology and Cardiovascular Medicine
business
circulatory and respiratory physiology
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....ef3e24b41b03f6182b565a839096b999