Correlation between Fundus Autofluorescence and En Face OCT Measurements of Geographic Atrophy

To evaluate the correlation between fundus autofluorescence (FAF) and en face spectral-domain OCT (SD-OCT) measurements of geographic atrophy (GA) area associated with age-related macular degeneration.Retrospective, cross-sectional study.Two hundred seventy eyes from 172 subjects with GA associated with age-related macular degeneration.Subjects with atrophic age-related macular degeneration who underwent both FAF (Heidelberg HRA + Spectralis) and dense volume (128 B-scans over 6 × 6 mmCorrelation between the SD-OCT and FAF measurements of the GA area.The mean GA area measured from the FAF images was 8.1 ± 5.04 mmSpectral-domain OCT-derived measurements of GA correlate well with areas of DDAF obtained from FAF images. The manual correction of SD-OCT segmentation errors can further improve this correlation. These observations may support the use of SD-OCT-based measurements of the GA area in clinical research and clinical trials.