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'Beware man's best friend'
- Source :
- Spine, Spine, Lippincott, Williams & Wilkins, 2010, 35 (25), pp.E1520-1
- Publication Year :
- 2010
- Publisher :
- HAL CCSD, 2010.
-
Abstract
- Study Design. Case report. Objective. To illustrate the usefulness of broad-range bacterial polymerase-chain-reaction (PCR) testing in osteoarticular infections by Capnocytophaga canimorsus. Summary of Background Data. C. canimorsus is a Gram-negative bacillus that was first identified in 1976. It is a normal inhabitant of the oral mucosa of dogs (26%) and cats (15%). The main clinical patterns are septicemia, which may cause fatal septic shock (in 30% of cases) but arthritis and discitis are possible. C. canimorsus is susceptible to many antimicrobials including β-lactam antibiotics. Methods. About a case report of 54-year-old man transferred to our institution for discitis, we discuss about PCR for C. canimorsus discitis diagnosis. Results. At admission, the only abnormal physical finding was global pain and stiffness of the lumbar spine. Radiographs of the lumbar spine and pelvis showed lumbar spondylosis, degenerative disc disease, and previously known degenerative facet joint disease. Magnetic resonance imaging indicated L3–L4 discitis with damage to both vertebrae and adjacent discs. Findings were negative from blood and urine cultures, serological tests for the HIV and brucellosis, and sputum tests for Mycobacterium tuberculosis. A percutaneous biopsy of the L3–L4 disc was performed but the bacteriological studies recovered no organisms. A second needle biopsy was performed for broad-range 16S rDNA PCR testing, which identified C. canimorsus. Conclusion. Broad-range PCR provided the microbiological diagnosis of culture-negative discitis in our patient. Broad-range PCR should be considered in patients with culture-negative osteoarticular infections.
- Subjects :
- Male
musculoskeletal diseases
medicine.medical_specialty
Discitis
[SDV.IMM] Life Sciences [q-bio]/Immunology
Arthritis
Polymerase Chain Reaction
Degenerative disc disease
Facet joint
MESH: Dogs
MESH: Lumbar Vertebrae
Dogs
Internal medicine
medicine
MESH: Gram-Negative Bacterial Infections
Animals
Humans
Orthopedics and Sports Medicine
MESH: Animals
Lumbar Vertebrae
MESH: Humans
MESH: Middle Aged
biology
Septic shock
business.industry
Brucellosis
MESH: Polymerase Chain Reaction
Capnocytophaga canimorsus
Middle Aged
medicine.disease
biology.organism_classification
MESH: Male
medicine.anatomical_structure
MESH: Discitis
Sputum
[SDV.IMM]Life Sciences [q-bio]/Immunology
Neurology (clinical)
medicine.symptom
business
Gram-Negative Bacterial Infections
Capnocytophaga
MESH: Capnocytophaga
Subjects
Details
- Language :
- English
- ISSN :
- 03622436
- Database :
- OpenAIRE
- Journal :
- Spine, Spine, Lippincott, Williams & Wilkins, 2010, 35 (25), pp.E1520-1
- Accession number :
- edsair.doi.dedup.....ef47f317d9825c13421f104d6d7c4777