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Longitudinal Modeling of Transmissible Risk in Boys Who Subsequently Develop Cannabis Use Disorder
Longitudinal Modeling of Transmissible Risk in Boys Who Subsequently Develop Cannabis Use Disorder
- Source :
- The American Journal of Drug and Alcohol Abuse. 39:180-185
- Publication Year :
- 2013
- Publisher :
- Informa UK Limited, 2013.
-
Abstract
- Risk for substance use disorder is frequently transmitted across generations due to significant heritability.This longitudinal study tests the hypothesis that initial exposure to cannabis in youths having high transmissible risk is a signal event promoting development of cannabis use disorder (CUD).At age 22, 412 men were classified into three groups: (1) lifetime CUD, (2) cannabis use without CUD, and (3) no lifetime cannabis use. Transmissible risk, quantified on a continuous scale using the previously validated transmissible liability index (TLI), along with cannabis use and CUD were documented at 10-12, 12-14, 16, 19, and 22 years of age.The CUD group scored higher on the TLI before they began cannabis use compared to the other two groups. In addition, a progressive increase in TLI severity was evinced by the CUD group beginning at the time of initiation of cannabis use whereas cannabis users who did not subsequently develop CUD exhibited a decline in transmissible risk following first exposure.Initial use of cannabis potentiates development of CUD in youths who are at high transmissible risk but is inconsequential in youths having low risk. The practical ramifications of these results for prevention are discussed.
- Subjects :
- Male
Marijuana Abuse
medicine.medical_specialty
Longitudinal study
Adolescent
media_common.quotation_subject
Medicine (miscellaneous)
Marijuana Smoking
Risk Assessment
Article
Cohort Studies
Young Adult
Risk Factors
medicine
Humans
Longitudinal Studies
Young adult
Child
Psychiatry
Cannabis use disorder
media_common
Models, Statistical
biology
Addiction
Age Factors
medicine.disease
biology.organism_classification
United States
Substance abuse
Psychiatry and Mental health
Clinical Psychology
Cannabis
Psychology
Risk assessment
Cohort study
Subjects
Details
- ISSN :
- 10979891 and 00952990
- Volume :
- 39
- Database :
- OpenAIRE
- Journal :
- The American Journal of Drug and Alcohol Abuse
- Accession number :
- edsair.doi.dedup.....ef4a7e860c15aa4626fd7cb27088ba83
- Full Text :
- https://doi.org/10.3109/00952990.2013.774009