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Age and sex impact plasma NFL and t-Tau trajectories in individuals with subjective memory complaints: a 3-year follow-up study
- Source :
- Alzheimer's Research & Therapy, Alzheimer's Research & Therapy, 2020, 12 (1), pp.147. ⟨10.1186/s13195-020-00704-4⟩, ALZHEIMERS RESEARCH & THERAPY, Alzheimer's research & therapy, vol 12, iss 1, Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-12 (2020)
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- Background Plasma neurofilament light (NFL) and total Tau (t-Tau) proteins are candidate biomarkers for early stages of Alzheimer’s disease (AD). The impact of biological factors on their plasma concentrations in individuals with subjective memory complaints (SMC) has been poorly explored. We longitudinally investigate the effect of sex, age, APOE ε4 allele, comorbidities, brain amyloid-β (Aβ) burden, and cognitive scores on plasma NFL and t-Tau concentrations in cognitively healthy individuals with SMC, a condition associated with AD development. Methods Three hundred sixteen and 79 individuals, respectively, have baseline and three-time point assessments (at baseline, 1-year, and 3-year follow-up) of the two biomarkers. Plasma biomarkers were measured with an ultrasensitive assay in a mono-center cohort (INSIGHT-preAD study). Results We show an effect of age on plasma NFL, with women having a higher increase of plasma t-Tau concentrations compared to men, over time. The APOE ε4 allele does not affect the biomarker concentrations while plasma vitamin B12 deficiency is associated with higher plasma t-Tau concentrations. Both biomarkers are correlated and increase over time. Baseline NFL is related to the rate of Aβ deposition at 2-year follow-up in the left-posterior cingulate and the inferior parietal gyri. Baseline plasma NFL and the rate of change of plasma t-Tau are inversely associated with cognitive score. Conclusion We find that plasma NFL and t-Tau longitudinal trajectories are affected by age and female sex, respectively, in SMC individuals. Exploring the influence of biological variables on AD biomarkers is crucial for their clinical validation in blood.
- Subjects :
- Male
BIOMARKER
0301 basic medicine
Oncology
Aging
Neurology
[SDV]Life Sciences [q-bio]
Disease
Neurodegenerative
Alzheimer's Disease
Medical and Health Sciences
lcsh:RC346-429
MESH: Cognitive Dysfunction
Alzheimer’s disease
Biomarkers
Mild cognitive impairment
Neurofilament light chain
Subjective memory complainers
Tau
0302 clinical medicine
Neurofilament Proteins
Medicine and Health Sciences
BRAIN
MESH: Neurofilament Proteins
RISK
Settore FIS/07
NEURODEGENERATION
Cognition
ASSOCIATION
MESH: Follow-Up Studies
Alzheimer's disease
MESH: Amyloid beta-Peptides
MESH: tau Proteins
ALZHEIMERS-DISEASE
POSITIVITY
Neurological
Cohort
Biomarker (medicine)
Female
medicine.medical_specialty
Cognitive Neuroscience
tau Proteins
Subjective
Affect (psychology)
VALIDATION
lcsh:RC321-571
subjective memory complainers
mild cognitive impairment
biomarkers
s disease
03 medical and health sciences
memory complainers
Clinical Research
Alzheimer Disease
Internal medicine
NEUROFILAMENT LIGHT-CHAIN
Acquired Cognitive Impairment
medicine
Humans
Cognitive Dysfunction
Vitamin B12
Allele
Alzheimer’
lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry
lcsh:Neurology. Diseases of the nervous system
Amyloid beta-Peptides
MESH: Humans
business.industry
Research
Prevention
Neurosciences
Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD)
Alzheimer Precision Medicine Initiative
COGNITIVE IMPAIRMENT
MESH: Male
Brain Disorders
030104 developmental biology
MESH: Biomarkers
Dementia
Neurology (clinical)
business
INSIGHT-preAD study group
MESH: Female
MESH: Alzheimer Disease
030217 neurology & neurosurgery
Follow-Up Studies
Subjects
Details
- ISSN :
- 17589193
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Alzheimer's Research & Therapy
- Accession number :
- edsair.doi.dedup.....ef4df428c2099eed80c3e4d65b4faa29