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Alternations in the gut microbiota and metabolome with newly diagnosed unstable angina

Authors :
Xuezhen Liu
Miaoyan Shen
Han Yan
Pinpin Long
Haijing Jiang
Yizhi Zhang
Lue Zhou
Kuai Yu
Gaokun Qiu
Handong Yang
Xiulou Li
Xinwen Min
Meian He
Xiaomin Zhang
Hyungwon Choi
Chaolong Wang
Tangchun Wu
Source :
Journal of Genetics and Genomics. 49:240-248
Publication Year :
2022
Publisher :
Elsevier BV, 2022.

Abstract

Gut microbiota plays an important role in coronary heart disease, but its compositional and functional changes in unstable angina (UA) remain unexplored. We performed metagenomic sequencing of 133 newly diagnosed UA patients and 133 sex- and age-matched controls, and profiled the fecal and plasma metabolomes in 30 case-control pairs. The alpha diversity of gut microbiota was increased in UA patients: the adjusted odds ratios (ORs) per standard deviation increase in Shannon and Simpson indices were 1.30 (95% confidence interval, 1.01-1.70) and 1.36 (1.05-1.81), respectively. Two common species (depleted Klebsiella pneumoniae and enriched Streptococcus parasanguinis; P ≤ 0.002) and three rare species (depleted Weissella confusa, enriched Granulicatella adiacens and Erysipelotrichaceae bacterium 6_1_45; P ≤ 0.005) were associated with UA. The UA-associated gut microbiota was depleted in the pathway of L-phenylalanine degradation (P = 0.001), primarily contributed by Klebsiella pneumoniae. Consistently, we found increased circulating phenylalanine in UA patients (OR = 2.76 [1.17-8.16]). Moreover, Streptococcusparasanguinis was negatively correlated with fecal citrulline (Spearman's r

Details

ISSN :
16738527
Volume :
49
Database :
OpenAIRE
Journal :
Journal of Genetics and Genomics
Accession number :
edsair.doi.dedup.....ef5248a875bd23cc19b8b83bf27ef462
Full Text :
https://doi.org/10.1016/j.jgg.2021.11.009