Smart chitosan-folate hybrid magnetic nanoparticles for targeted delivery of doxorubicin to osteosarcoma cells

Authors :: Nazanin Amiryaghoubi
Elaheh Dalir Abdolahinia
Ailar Nakhlband
Shaghayegh Aslzad
Marziyeh Fathi
Jaleh Barar
Yadollah Omidi
Source :: Colloids and surfaces. B, Biointerfaces. 220
Publication Year :: 2022
Abstract: Chitosan (CS)-based pH-sensitive nanocomposites were fabricated for the targeted delivery of doxorubicin (DOX) to osteosarcoma cells. To prepare the nanocomposite, CS was functionalized with succinic anhydride (SA) (CS-SA). CS-folic acid (FA) conjugates were produced by the conjugation of CS with FA via an amide bond. Next, Fe

Subjects :: Chitosan
Osteosarcoma
Drug Carriers
Surfaces and Interfaces
General Medicine
Colloid and Surface Chemistry
Folic Acid
Drug Delivery Systems
Doxorubicin
Spectroscopy, Fourier Transform Infrared
Humans
Nanoparticles
Physical and Theoretical Chemistry
Magnetite Nanoparticles
Biotechnology

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