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Child development following in utero exposure:levetiracetam vs sodium valproate
- Source :
- Shallcross, R, Bromley, R L, Irwin, B, Bonnett, L J, Morrow, J, Baker, G A, Fryer, A, Kneen, R, Banka, S, Briggs, M, Clayton-Smith, J, Mawer, G, Baker, G, Bromley, R, Dixon, P, Gummery, A, Shallcross, R, Kerr, L, Craig, J, Hunt, S, Irwin, B, Morrison, P, Morrow, J, Delanty, N, Liggan, B, Russell, A, Smithson, H, Parsons, L & Robertson, I 2011, ' Child development following in utero exposure : levetiracetam vs sodium valproate. ', Neurology, vol. 76, no. 4, pp. 383-389 . https://doi.org/10.1212/WNL.0b013e3182088297
- Publication Year :
- 2011
-
Abstract
- Children born to women with epilepsy (WWE), exposed in utero to levetiracetam (LEV, n = 51), were assessed for early cognitive development and compared to children exposed to sodium valproate in utero (VPA, n = 44) and a group of children representative of the general population (n = 97).Children were recruited prospectively from 2 cohorts in the United Kingdom and assessed using the Griffiths Mental Development Scale (1996), aged24 months. Information regarding maternal demographics were collected and controlled for. This is an observational study with researchers not involved in the clinical management of the WWE.On overall developmental ability, children exposed to LEV obtained higher developmental scores when compared to children exposed to VPA (p0.001). When compared, children exposed to LEV did not differ from control children (p = 0.62) on overall development. Eight percent of children exposed to LEV in utero fell within the below average range (DQ score of84), compared with 40% of children exposed to VPA. After controlling for maternal epilepsy and demographic factors using linear regression analysis, exposure to LEV in utero was not associated with outcome (p = 0.67). Conversely, when compared with VPA exposure, LEV exposure was associated with higher scores for the overall developmental quotient (p0.001).Children exposed to LEV in utero are not at an increased risk of delayed early cognitive development under the age of 24 months. LEV may therefore be a preferable drug choice, where appropriate, for WWE prior to and of childbearing age.
- Subjects :
- Pediatrics
medicine.medical_specialty
Levetiracetam
Population
Clinical Neurology
Epilepsy
Child Development
Cognition
Pregnancy
Humans
Medicine
education
Maternal-Fetal Exchange
Retrospective Studies
Valproic Acid
education.field_of_study
business.industry
Infant
Articles
medicine.disease
Piracetam
Child development
Pregnancy Complications
El Niño
Maternal Exposure
In utero
Child, Preschool
Prenatal Exposure Delayed Effects
Anticonvulsants
Female
Neurology (clinical)
business
medicine.drug
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Shallcross, R, Bromley, R L, Irwin, B, Bonnett, L J, Morrow, J, Baker, G A, Fryer, A, Kneen, R, Banka, S, Briggs, M, Clayton-Smith, J, Mawer, G, Baker, G, Bromley, R, Dixon, P, Gummery, A, Shallcross, R, Kerr, L, Craig, J, Hunt, S, Irwin, B, Morrison, P, Morrow, J, Delanty, N, Liggan, B, Russell, A, Smithson, H, Parsons, L & Robertson, I 2011, ' Child development following in utero exposure : levetiracetam vs sodium valproate. ', Neurology, vol. 76, no. 4, pp. 383-389 . https://doi.org/10.1212/WNL.0b013e3182088297
- Accession number :
- edsair.doi.dedup.....ef72aa803b32e039cce35d82b745a6bb