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Scrutinizing the triad of Vibrio tapetis, the skin barrier and pigmentation as determining factors in the development of skin ulcerations in wild common dab (Limanda limanda)
- Source :
- Veterinary Research, Veterinary Research, Vol 50, Iss 1, Pp 1-13 (2019), Veterinary Research, BioMed Central, 2019, 50 (1), pp.41. ⟨10.1186/s13567-019-0659-6⟩, Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela, instname, VETERINARY RESEARCH
- Publication Year :
- 2019
- Publisher :
- BioMed Central, 2019.
-
Abstract
- Recently, Vibrio tapetis was isolated for the first time from skin ulcerations in wild-caught common dab (Limanda limanda). To further examine its role in the development of these skin lesions, an in vivo experiment was performed. The significance of the skin barrier and in addition the difference between pigmented and non-pigmented side were investigated. Hence, the skin of common dab was treated in three different ways on both the pigmented and non-pigmented side. On a first “treatment zone”, the scales and overlying epidermal tissue were removed whereas in a second zone only the mucus was discarded. The third zone served as a non-treated zone. Thereafter, fish were challenged with V. tapetis. The control group was sham treated. Mortality, clinical signs, severity and size of the developing lesions were recorded. All animals were sacrificed and sampled 21 days post-inoculation. Significantly more fish of the group challenged with V. tapetis died compared to the control group with the highest incidence occurring 4 days post-inoculation. Fish challenged with V. tapetis developed more severe skin ulcerations. In zones where scales and epidermal tissue were removed, the ulcerations were more severe compared to zones where only mucus was eliminated. Ulcerations occurred more frequently, were more severe and larger on the pigmented side. Our data represents prove of V. tapetis as causative agent of ulcerative skin lesions although prior damage of the skin seems to be a major contributing factor. Furthermore, the pigmented side seemed predisposed to the development of skin ulcerations. The research was funded by the European Fisheries Fund (EVF-project VIS/15/A03/DIV), the Flemish Government and the Research Foundation—Flanders (FWO). This work makes use of resources, facilities and/or services provided by UGent and Flanders Marine Institute as part of the Belgian contribution to EMBRC-ERIC SI
- Subjects :
- 0301 basic medicine
Pathology
medicine.medical_specialty
Skin barrier
STRESS
MUCUS
040301 veterinary sciences
[SDV]Life Sciences [q-bio]
CORKWING WRASSE
DUTCH WADDEN SEA
0403 veterinary science
03 medical and health sciences
Fish Diseases
Flatfish
ULCER DISEASE
ATLANTIC SALMON
Skin Physiological Phenomena
Skin Ulcer
medicine
Animals
Limanda
Veterinary Sciences
14. Life underwater
Vibrio
lcsh:Veterinary medicine
General Veterinary
biology
integumentary system
Pigmentation
STRAINS
SYMPHODUS-MELOPS
Common dab
EPIDERMAL PAPILLOMA
Skin ulcerations
04 agricultural and veterinary sciences
Skin Diseases, Bacterial
biology.organism_classification
Mucus
3. Good health
Vibrio tapetis
030104 developmental biology
Vibrio Infections
Flatfishes
lcsh:SF600-1100
FLOUNDER PLATICHTHYS-FLESUS
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 12979716 and 09284249
- Volume :
- 50
- Database :
- OpenAIRE
- Journal :
- Veterinary Research
- Accession number :
- edsair.doi.dedup.....ef75a5231013e2d2490d67e9e1ba95e9