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Defining the major health modifiers causing atrial fibrillation: a roadmap to underpin personalized prevention and treatment
- Source :
- Nature Reviews Cardiology. 13:230-237
- Publication Year :
- 2015
- Publisher :
- Springer Science and Business Media LLC, 2015.
-
Abstract
- Despite remarkable advances in antiarrhythmic drugs, ablation procedures, and stroke-prevention strategies, atrial fibrillation (AF) remains an important cause of death and disability in middle-aged and elderly individuals. Unstructured management of patients with AF sharply contrasts with our detailed, although incomplete, knowledge of the mechanisms that cause AF and its complications. Altered calcium homeostasis, atrial fibrosis and ageing, ion-channel dysfunction, autonomic imbalance, fat-cell infiltration, and oxidative stress, in addition to a susceptible genetic background, contribute to the promotion, maintenance, and progression of AF. However, clinical management of patients with AF is currently guided by stroke risk parameters, AF pattern, and symptoms. In response to this apparent disconnect between the known pathophysiology of AF and clinical management, we propose a roadmap to develop a set of clinical markers that reflect the major causes of AF in patients. Thereby, the insights into the mechanisms causing AF will be transformed into a format that can underpin future personalized strategies to prevent and treat AF, ultimately informing better patient care.
- Subjects :
- medicine.medical_specialty
business.industry
Long QT syndrome
Expert consensus
Atrial fibrillation
030204 cardiovascular system & hematology
Precision medicine
medicine.disease
law.invention
03 medical and health sciences
0302 clinical medicine
Randomized controlled trial
law
medicine
Physical therapy
030212 general & internal medicine
Risk factor
Cardiology and Cardiovascular Medicine
Risk assessment
Intensive care medicine
business
Cause of death
Subjects
Details
- ISSN :
- 17595010 and 17595002
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Nature Reviews Cardiology
- Accession number :
- edsair.doi.dedup.....ef8d0a2ef5a542757894ce96e7d379f4