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Human skin equivalents: Impaired barrier function in relation to the lipid and protein properties of the stratum corneum
- Source :
- Advanced Drug Delivery Reviews, Advanced Drug Delivery Reviews, 175
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- To advance drug development representative reliable skin models are indispensable. Animal skin as test model for human skin delivery is restricted as their properties greatly differ from human skin. In vitro 3D-human skin equivalents (HSEs) are valuable tools as they recapitulate important aspects of the human skin. However, HSEs still lack the full barrier functionality as observed in native human skin, resulting in suboptimal screening outcome. In this review we provide an overview of established in-house and commercially available HSEs and discuss in more detail to what extent their skin barrier biology is mimicked in vitro focusing on the lipid properties and cornified envelope. Further, we will illustrate how underlying factors, such as culture medium improvements and environmental factors affect the barrier lipids. Lastly, potential improvements in skin barrier function will be proposed aiming at a new generation of HSEs that may replace animal skin delivery studies fully.
- Subjects :
- Skin barrier
Pharmaceutical Science
Human skin
02 engineering and technology
Permeability
Cornified envelope
03 medical and health sciences
Stratum corneum
medicine
Humans
Cells, Cultured
Skin barrier function
Barrier function
030304 developmental biology
Skin, Artificial
0303 health sciences
integumentary system
Chemistry
Proteins
021001 nanoscience & nanotechnology
Lipids
Cell biology
medicine.anatomical_structure
Drug development
0210 nano-technology
Animal skin
Subjects
Details
- ISSN :
- 0169409X
- Volume :
- 175
- Database :
- OpenAIRE
- Journal :
- Advanced Drug Delivery Reviews
- Accession number :
- edsair.doi.dedup.....efa4dab29982d17afa203d5ebad8f31e