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A case of antisynthetase syndrome in a rheumatoid arthritis patient with anti-PL-12 antibody following treatment with etanercept
- Source :
- Clinical rheumatology. 30(3)
- Publication Year :
- 2010
-
Abstract
- In our earlier study, we had reported the case of a patient with rheumatoid arthritis (RA), who had anti-Jo-1 antibodies. This patient had received etanercept (ETN) therapy for RA, after which she had developed overt polymyositis (PM). Although various autoimmune phenomena, including lupus-like diseases, vasculitides, or psoriatic skin lesions, are associated with antitumor necrosis factor (TNF) therapy, the development of PM/dermatomyositis (DM) or antisynthetase syndrome following anti-TNF therapy is extremely rare. Here, we report a case of an RA patient with anti-PL-12 antibodies, who received ETN therapy and subsequently developed the antisynthetase syndrome. She recovered when ETN therapy was withdrawn and high-dose corticosteroid was administered. To date, there have been only five reported cases of RA patients with anti-Jo-1 antibodies who developed overt PM/DM following anti-TNF therapy and only one case of antisynthetase syndrome in an RA patient with anti-PL-7 antibodies. Our patients and the abovementioned reports strongly suggest that onset of overt PM/DM or antisynthetase syndrome in RA patients with anti-aminoacyl tRNA synthetase antibodies is associated with anti-TNF therapy.
- Subjects :
- medicine.medical_specialty
medicine.drug_class
Antisynthetase syndrome
Gastroenterology
Polymyositis
Receptors, Tumor Necrosis Factor
Etanercept
Amino Acyl-tRNA Synthetases
Arthritis, Rheumatoid
Rheumatology
Internal medicine
Adverse drug effect
Medicine
Humans
Anti-ARS antibodies
biology
Myositis
business.industry
Anti-TNF therapy
General Medicine
Dermatomyositis
Middle Aged
medicine.disease
Antibodies, Anti-Idiotypic
Rheumatoid arthritis
Antirheumatic Agents
Immunoglobulin G
Immunology
biology.protein
Corticosteroid
Polymyositis/dermatomyositis
Tumor necrosis factor alpha
Female
Antibody
business
medicine.drug
Subjects
Details
- ISSN :
- 14349949
- Volume :
- 30
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Clinical rheumatology
- Accession number :
- edsair.doi.dedup.....efb3fe0ae961383b1ff236759c4fed93