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Parental occupational exposures in wood-related jobs and risk of testicular germ cell tumours in offspring in NORD-TEST a registry-based case-control study in Finland, Norway, and Sweden
- Source :
- Corbin, S, Togawa, K, Schüz, J, Le Cornet, C, Fervers, B, Feychting, M, Wiebert, P, Hansen, J, Dalton, S O, Kjærheim, K, Nordby, K C, Østrem, R S, Skakkebæk, N E, Uuksulainen, S, Pukkala, E & Olsson, A 2022, ' Parental occupational exposures in wood-related jobs and risk of testicular germ cell tumours in offspring in NORD-TEST a registry-based case–control study in Finland, Norway, and Sweden ', International Archives of Occupational and Environmental Health, vol. 95, pp. 1243–1253 . https://doi.org/10.1007/s00420-021-01818-4
- Publication Year :
- 2021
-
Abstract
- Objective We assessed the association between parental prenatal exposures in wood-related jobs and risk of testicular germ cell tumours (TGCT) in offspring. Methods NORD-TEST, a registry-based case–control study in Sweden, Finland and Norway, included 8112 TGCT cases diagnosed at ages 14–49 years between 1978 and 2012 with no history of prior cancer, and up to four controls matched to each case on year and country of birth. Parents of cases and controls were identified via linkages with the population registries and their occupational information was retrieved from censuses. The Nordic Occupational Cancer Study Job-Exposure Matrix was used to assign occupational exposures to each parent. Logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CI). Results Maternal wood-related job was not associated with the risk of TGCT in offspring (OR 1.08, CI 0.55–2.14), while paternal wood-related job was associated with a decreased risk of TGCT in offspring (OR 0.85, CI 0.75–0.96). None of the specific wood-related jobs, such as upholsterers, sawyers, or construction carpenters, were significantly associated with a risk of TGCT. Only exception was observed in a sensitivity analysis which showed an increased risk in the small group of sons of fathers working as ‘cabinetmakers and joiners’ the year before conception (OR of 2.06, CI 1.00–4.25). Conclusion This large-scale NORD-TEST analysis provided no evidence of an association between parental prenatal exposures in wood-related jobs and TGCT in sons.
- Subjects :
- Adult
Male
Occupational cancer
Testicular neoplasms
Adolescent
Offspring
Population
Logistic regression
Young Adult
Testicular Neoplasms
Pregnancy
Risk Factors
Occupational Exposure
medicine
Humans
Registries
education
Finland
Sweden
education.field_of_study
business.industry
Norway
Public Health, Environmental and Occupational Health
Case-control study
Cancer
Odds ratio
Prenatal exposure delayed effects
Occupational exposure
Middle Aged
Neoplasms, Germ Cell and Embryonal
medicine.disease
Wood-related jobs
Wood
Confidence interval
3141 Health care science
Nordic countries
Case-Control Studies
Testicular germ cell tumours
Female
business
Demography
Subjects
Details
- ISSN :
- 14321246
- Volume :
- 95
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- International archives of occupational and environmental health
- Accession number :
- edsair.doi.dedup.....efb8310755821cdfb13dceec05a9246d
- Full Text :
- https://doi.org/10.1007/s00420-021-01818-4