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Parental occupational exposures in wood-related jobs and risk of testicular germ cell tumours in offspring in NORD-TEST a registry-based case-control study in Finland, Norway, and Sweden

Authors :
Ragnhild Strand Østrem
Susanne Oksbjerg Dalton
Kristina Kjærheim
Sara Corbin
Niels E. Skakkebæk
Ann Olsson
Joachim Schüz
Karl-Christian Nordby
Kayo Togawa
Maria Feychting
Béatrice Fervers
Pernilla Wiebert
Charlotte Le Cornet
Sanni Uuksulainen
Johnni Hansen
Eero Pukkala
Tampere University
Health Sciences
Source :
Corbin, S, Togawa, K, Schüz, J, Le Cornet, C, Fervers, B, Feychting, M, Wiebert, P, Hansen, J, Dalton, S O, Kjærheim, K, Nordby, K C, Østrem, R S, Skakkebæk, N E, Uuksulainen, S, Pukkala, E & Olsson, A 2022, ' Parental occupational exposures in wood-related jobs and risk of testicular germ cell tumours in offspring in NORD-TEST a registry-based case–control study in Finland, Norway, and Sweden ', International Archives of Occupational and Environmental Health, vol. 95, pp. 1243–1253 . https://doi.org/10.1007/s00420-021-01818-4
Publication Year :
2021

Abstract

Objective We assessed the association between parental prenatal exposures in wood-related jobs and risk of testicular germ cell tumours (TGCT) in offspring. Methods NORD-TEST, a registry-based case–control study in Sweden, Finland and Norway, included 8112 TGCT cases diagnosed at ages 14–49 years between 1978 and 2012 with no history of prior cancer, and up to four controls matched to each case on year and country of birth. Parents of cases and controls were identified via linkages with the population registries and their occupational information was retrieved from censuses. The Nordic Occupational Cancer Study Job-Exposure Matrix was used to assign occupational exposures to each parent. Logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CI). Results Maternal wood-related job was not associated with the risk of TGCT in offspring (OR 1.08, CI 0.55–2.14), while paternal wood-related job was associated with a decreased risk of TGCT in offspring (OR 0.85, CI 0.75–0.96). None of the specific wood-related jobs, such as upholsterers, sawyers, or construction carpenters, were significantly associated with a risk of TGCT. Only exception was observed in a sensitivity analysis which showed an increased risk in the small group of sons of fathers working as ‘cabinetmakers and joiners’ the year before conception (OR of 2.06, CI 1.00–4.25). Conclusion This large-scale NORD-TEST analysis provided no evidence of an association between parental prenatal exposures in wood-related jobs and TGCT in sons.

Details

ISSN :
14321246
Volume :
95
Issue :
6
Database :
OpenAIRE
Journal :
International archives of occupational and environmental health
Accession number :
edsair.doi.dedup.....efb8310755821cdfb13dceec05a9246d
Full Text :
https://doi.org/10.1007/s00420-021-01818-4