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Organophosphorus pesticides can influence the development of obesity and type 2 diabetes with concomitant metabolic changes

Authors :
Krzysztof Sawicki
Berta Fal
Bartłomiej Drop
Barbara Jodłowska-Jędrych
Magdalena Matysiak-Kucharek
Magdalena Czajka
Lucyna Kapka-Skrzypczak
Marcin Kruszewski
Source :
Environmental research. 178
Publication Year :
2018

Abstract

Widespread use and the bioaccumulation of pesticides in the environment lead to the contamination of air, water, soil and agricultural resources. A huge body of evidence points to the association between the pesticide exposure and increase in the incidence of chronic diseases, e.g. cancer, birth defects, reproductive disorders, neurodegenerative, cardiovascular and respiratory diseases, developmental disorders, metabolic disorders, chronic renal disorders or autoimmune diseases. Organophosphorus compounds are among the most widely used pesticides. A growing body of evidence is suggesting the potential interdependence between the organophosphorus pesticides (OPs) exposure and risk of obesity and type 2 diabetes mellitus (T2DM). This article reviews the current literature to highlight the latest in vitro and in vivo evidences on the possible influence of OPs on obesity and T2DM development, as well as epidemiological evidence for the metabolic toxicity of OPs in humans. The article also draws attention to the influence of maternal OPs exposure on offspring. Summarized studies suggest that OPs exposure is associated with metabolic changes linked with obesity and T2DM indicated that such exposures may increase risk or vulnerability to other contributory components.

Details

ISSN :
10960953
Volume :
178
Database :
OpenAIRE
Journal :
Environmental research
Accession number :
edsair.doi.dedup.....efbb12b304f44d5eec31a162c88a026a