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Wheezing phenotypes in young children: an historical cohort study
Wheezing phenotypes in young children: an historical cohort study
- Source :
- Primary Care Respiratory Journal: Journal of the General Practice Airways Group
- Publication Year :
- 2014
- Publisher :
- Springer Science and Business Media LLC, 2014.
-
Abstract
- Background: Wheezing phenotypes in young children have usually been described on the basis of questionnaire surveys instead of prospectively doctor-diagnosed episodes, and have never been described in terms of incidence rates. Aims: To identify wheezing phenotypes in the first three years and describe their incidence trends, and to investigate their relationship with asthma at six years of age. Methods: Doctor-diagnosed wheezing episodes in the first 36 months and active asthma at six years were identified in a historical cohort of 3,739 children followed from birth in 29 primary care health centres in Spain. Wheezing phenotypes were identified by means of latent class analysis. Changes in incidence rates of wheezing were identified through joinpoint regression models and their predictive ability for asthma was analysed. Results: One never/infrequent wheeze phenotype and three wheezing phenotypes were identified. There were two early phenotypes which started wheezing at a median age of six months, one of which was transient while the other had a heavy recurrence of episodes. A third phenotype exhibited a delayed onset of wheezing, a constant rise in incidence through the first 36 months, and a relationship with allergic asthma. These three phenotypes had a higher prevalence of active asthma at six years than the never/infrequent wheeze phenotype, but the classification had a weak predictive ability for asthma due to low sensitivity. Conclusions: The use of incidence rates contributes to the clarification of the natural history of infant wheezing.
- Subjects :
- Male
Pulmonary and Respiratory Medicine
Pediatrics
medicine.medical_specialty
cohort studies
Wheeze
Humans
Medicine
Respiratory sounds
Asthma
child
medicine.diagnostic_test
business.industry
Incidence (epidemiology)
Public Health, Environmental and Occupational Health
asthma
medicine.disease
infant
Latent class model
respiratory sounds
Natural history
Phenotype
Female
medicine.symptom
business
Historical Cohort
Research Paper
Cohort study
Subjects
Details
- ISSN :
- 14751534 and 14714418
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- Primary Care Respiratory Journal
- Accession number :
- edsair.doi.dedup.....efbc76704211d77dfd941163025e5005
- Full Text :
- https://doi.org/10.4104/pcrj.2014.00008