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Mercury influences rat liver tyrosine aminotransferase activity and induction by dexamethasone
- Source :
- Journal of Applied Toxicology. 26:187-190
- Publication Year :
- 2006
- Publisher :
- Wiley, 2006.
-
Abstract
- The effects of mercury (Hg) on basal and dexamethasone-induced tyrosine aminotransferase (TAT) activity in rat liver were studied. Comparison of TAT activity after in vitro and in vivo mercury application revealed the influence of the metal only when applied in vivo, suggesting that the effects are expressed at the level of TAT gene transcription. Intraperitoneal administration of mercury at 1, 2 or 3 mg Hg kg−1 b.w. 4 h before decapitation was shown to stimulate the basal activity of TAT. The most prominent increase was observed 4 h after the metal administration. When applied at 1 and 2 mg Hg kg−1 b.w. mercury was also shown to reduce partially the extent of the enzyme induction by dexamethasone, which was injected intraperitoneally at 5 mg kg−1 b.w. 5 h before death. The highest dose of mercury (3 mg Hg kg−1 b.w.) almost completely abolished the dexamethasone effect. The finding that mercury increases basal activity of the enzyme while decreasing its induction by dexamethasone suggests that stimulatory effects of this metal on TAT activity are probably mediated by factors other than glucocorticoids. Copyright © 2005 John Wiley & Sons, Ltd.
- Subjects :
- medicine.medical_specialty
medicine.drug_class
medicine.medical_treatment
Tyrosine Transaminase
Anti-Inflammatory Agents
chemistry.chemical_element
Toxicology
Dexamethasone
Cytosol
Receptors, Glucocorticoid
Tyrosine aminotransferase
In vivo
Internal medicine
medicine
Animals
Enzyme inducer
biology
Spectrophotometry, Atomic
Mercury
Rats
Mercury (element)
Steroid hormone
Endocrinology
Liver
chemistry
Enzyme Induction
biology.protein
Corticosteroid
medicine.drug
Subjects
Details
- ISSN :
- 10991263 and 0260437X
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Journal of Applied Toxicology
- Accession number :
- edsair.doi.dedup.....efc5dec32a69aa2c9fea77a8377fadf2