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Autism spectrum disorders are associated with an elevated autoantibody response to tissue transglutaminase-2
- Source :
- Autism Research. 4:242-249
- Publication Year :
- 2011
- Publisher :
- Wiley, 2011.
-
Abstract
- We report that a significant number of autistic children have serum levels of IgA antibodies above normal to the enzyme tissue transglutaminase II (TG2), and that expression of these antibodies to TG2 is linked to the (HLA)-DR3, DQ2 and DR7, DQ2 haplotypes. TG2 is expressed in the brain, where it has been shown to be important in cell adhesion and synaptic stabilization. Thus, these children appear to constitute a subpopulation of autistic children who fall within the autism disease spectrum, and for whom autoimmunity may represent a significant etiological component of their autism.
- Subjects :
- Male
medicine.medical_specialty
Adolescent
Tissue transglutaminase
HLA-DR7 Antigen
Enzyme-Linked Immunosorbent Assay
Human leukocyte antigen
medicine.disease_cause
Autoimmunity
HLA-DR3 Antigen
GTP-Binding Proteins
HLA-DQ Antigens
Internal medicine
medicine
Humans
Protein Glutamine gamma Glutamyltransferase 2
Child
Genetics (clinical)
Autoantibodies
Transglutaminases
biology
business.industry
General Neuroscience
Haplotype
medicine.disease
Endocrinology
Haplotypes
Child Development Disorders, Pervasive
Child, Preschool
Immunology
biology.protein
Etiology
Autism
Female
AUTOANTIBODY RESPONSE
Neurology (clinical)
Antibody
business
Subjects
Details
- ISSN :
- 19393792
- Volume :
- 4
- Database :
- OpenAIRE
- Journal :
- Autism Research
- Accession number :
- edsair.doi.dedup.....efe4a6bddb70f428983585af6f9431f2